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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-12-2010 | Research

Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects

Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Famela Ramos, Thomas E Ichim, Neil H Riordan

Published in: Journal of Translational Medicine | Issue 1/2010

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Abstract

The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising preclinical and early clinical data for several degenerative conditions, this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days 1, 2, 7, and 14 subsequent to initiation of administration, which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1/CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors.
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Metadata
Title
Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects
Authors
Nina A Mikirova
James A Jackson
Ron Hunninghake
Julian Kenyon
Kyle WH Chan
Cathy A Swindlehurst
Boris Minev
Amit N Patel
Michael P Murphy
Leonard Smith
Famela Ramos
Thomas E Ichim
Neil H Riordan
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-34

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