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Tumor Biology
Published in: Tumor Biology 3/2013

01-06-2013 | Research Article

Null genotype of glutathione S-transferase T1 contributes to increased risk of gastric cancer in Asian population

Authors: Wanli Zhang, Jing Huang, Gang Peng, Qian Ding, Jing Chen, Yawei Hua, Jun Xue

Published in: Tumor Biology | Issue 3/2013

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Abstract

Numerous studies were published to investigate the relationship between the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric cancer in Asians, but the conclusions from those studies were conflicting. To get a more precise estimation on the possible association, we performed a meta-analysis of published data. A comprehensive literature was conducted and 27 case–control studies with 14,905 individuals were finally included, involving a total of 6,270 cases and 8,635 controls. The strength of the association between GSTT1 polymorphism and gastric cancer risk was estimated by calculating the pooled odds ratio with its 95 % confidence interval (95 % CI). A meta-analysis of total 27 studies showed that GSTT1 null genotype was obviously associated with increased risk of gastric cancer in Asians (random effect odds ratio (OR) = 1.29, 95 % CI 1.16–1.44, P OR < 0.001). A subgroup analysis of 14 studies with large sample size also showed an obvious association between GSTT1 null genotype and increased risk of gastric cancer in Asians (fixed effect OR = 1.14, 95 % CI 1.06–1.23, P OR = 0.001). In conclusion, the meta-analysis suggests that null genotype of GSTT1 contributes to increased risk of gastric cancer in Asian population.
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Metadata
Title
Null genotype of glutathione S-transferase T1 contributes to increased risk of gastric cancer in Asian population
Authors
Wanli Zhang
Jing Huang
Gang Peng
Qian Ding
Jing Chen
Yawei Hua
Jun Xue
Publication date
01-06-2013
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 3/2013
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-0669-3

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