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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | NSCLC | Research

Does caring for patients with advanced non-small cell lung cancer affect health-related quality of life of caregivers? A multicenter, cross-sectional study

Authors: Yi Yang, Liu Liu, Jia Chen, Yuying Gan, Chunxia Su, Haibo Zhang, Enwu Long, Fei Yan, Yingyao Chen

Published in: BMC Public Health | Issue 1/2024

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Abstract

Purpose

Patients with advanced non-small cell lung cancer (NSCLC) mostly receive essential routine care and support from informal caregivers, who usually experience poorer health-related quality of life (HRQoL). The study aimed to evaluate the HRQoL and its predictors among informal caregivers of patients with advanced NSCLC in China.

Methods

We interviewed the adult caregiver population of patients with advanced NSCLC (stage IIIB~IV) in nine tertiary hospitals from multiple provinces in China between November 2020 and June 2021. The EQ-5D-5L instrument measured the HRQoL of caregivers, as analyzed by employing descriptive analysis, univariate analysis, Tobit regression, and multivariate logistic regression, and investigated the important influencing factors further.

Results

A valid sample of 553 caregivers was analyzed. The mean EQ-5D-5L utility score of caregivers was 0.92 (SD = 0.14). Caregivers reported the greatest problems in mental health, with 45.39% reporting slight, moderate, severe, or extreme anxiety/depression. The potential influencing factors of HRQoL in caregivers included patients' age and cancer histology, relationship with the patients, and daily caregiving hours. Compared to other caregivers, patients' spouses had the lowest HRQoL. In addition, over six hours of caregiving per day was associated with lower HRQoL in caregivers of patients with advanced NSCLC.

Conclusions

The HRQoL of caregivers for patients with advanced NSCLC was investigated for the first time in China. The informal caregivers experience decreased HRQoL, with anxiety /depression problems being reported the most. The findings of this study would provide extensive information on the HRQoL of advanced NSCLC patients' caregivers for future health-promoting self-care.
Literature
1.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.CrossRefPubMed
2.
Cao W, Chen HD, Yu YW, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 2021;134(7):783–91.CrossRefPubMed
3.
Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553(7689):446–54.PubMedCrossRef
4.
Jamal-Hanjani M, Wilson GA, McGranahan N, et al. Tracking the Evolution of Non-Small-Cell Lung Cancer. N Engl J Med. 2017;376(22):2109–21.PubMedCrossRef
5.
Sato T, Fujisawa D, Arai D, et al. Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study. Palliat Med. 2021;35(5):943–51.PubMedPubMedCentralCrossRef
6.
WU J, LIN Z. Non-Small cell lung cancer targeted therapy: drugs and mechanisms of drug resistance. Int J Mol Sci. 2022;23(23):15056.
7.
Chen P, Liu Y, Wen Y, et al. Non-small cell lung cancer in China. Cancer Commun (Lond). 2022;42(10):937–70.PubMedCrossRef
8.
Lindeman NI, Cagle PT, Aisner DL, et al. Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology. Arch Pathol Lab Med. 2018;142(3):321–46.PubMedCrossRef
9.
Cai J, Zhang L, Guerriere D, et al. Determinants of primary and non-primary informal care-giving to home-based palliative care cancer care-recipients in Ontario, Canada. Health Soc Care Community. 2021;29(6):e405–19.PubMedCrossRef
10.
11.
12.
Hu X, Peng X, Su Y, et al. Caregiver burden among Chinese family caregivers of patients with lung cancer: A cross-sectional survey. Eur J Oncol Nurs. 2018;37:74–80.PubMedCrossRef
13.
Grant M, Sun V, Fujinami R, et al. Family caregiver burden, skills preparedness, and quality of life in non-small cell lung cancer. Oncol Nurs Forum. 2013;40(4):337–46.PubMedPubMedCentralCrossRef
14.
15.
Fujinami R, Otis-Green S, Klein L, et al. Quality of life of family caregivers and challenges faced in caring for patients with lung cancer. Clin J Oncol Nurs. 2012;16(6):E210-220.PubMedPubMedCentralCrossRef
16.
Borges EL, Franceschini J, Costa LH, et al. Family caregiver burden: the burden of caring for lung cancer patients according to the cancer stage and patient quality of life. J Bras Pneumol. 2017;43(1):18–23.PubMedPubMedCentralCrossRef
17.
Al-Janabi H, Nicholls J, Oyebode J. The need to “carer proof” healthcare decisions. BMJ. 2016;352:i1651.PubMedCrossRef
18.
Pennington B, Eaton J, Hatswell AJ, et al. Carers’ Health-Related Quality of Life in Global Health Technology Assessment: Guidance, Case Studies and Recommendations. Pharmacoeconomics. 2022;40(9):837–50.PubMedPubMedCentralCrossRef
19.
Pennington BM. Inclusion of Carer Health-Related Quality of Life in National Institute for Health and Care Excellence Appraisals. Value Health. 2020;23(10):1349–57.PubMedCrossRef
20.
Al-Janabi H, Efstathiou N, McLoughlin C, et al. The scope of carer effects and their inclusion in decision-making: a UK-based Delphi study. BMC Health Serv Res. 2021;21(1):752.PubMedPubMedCentralCrossRef
21.
Shen Y, Wu B, Wang X, et al. Health state utilities in patients with advanced non-small-cell lung cancer in China [J]. J Comp Eff Res. 2018;7(5):443–52.PubMedCrossRef
22.
Nafees B, Lloyd AJ, Dewilde S, et al. Health state utilities in non-small cell lung cancer: an international study. Asia Pac J Clin Oncol. 2017;13(5):e195–203.PubMedCrossRef
23.
Witlox WJA, Ramaekers BLT, Joore MA, et al. Health-related quality of life after prophylactic cranial irradiation for stage III non-small cell lung cancer patients: Results from the NVALT-11/DLCRG-02 phase III study. Radiother Oncol. 2020;144:65–71.PubMedCrossRef
24.
Mazieres J, Kowalski D, Luft A, et al. Health-Related Quality of Life With Carboplatin-Paclitaxel or nab-Paclitaxel With or Without Pembrolizumab in Patients With Metastatic Squamous Non-Small-Cell Lung Cancer. J Clin Oncol. 2020;38(3):271–80.PubMedCrossRef
25.
26.
Luo N, Liu G, Li M, et al. Estimating an EQ-5D-5L Value Set for China. Value Health. 2017;20(4):662–9.PubMedCrossRef
27.
Del Río Lozano M, García-Calvente MDM, Calle-Romero J, et al. Health-related quality of life in Spanish informal caregivers: gender differences and support received. Qual Life Res. 2017;26(12):3227–38.
28.
Xie S, Wu J, Xie F. Population Norms for SF-6Dv2 and EQ-5D-5L in China. Appl Health Econ Health Policy. 2022;20(4):573–85.PubMedCrossRef
29.
30.
Arora S, Goodall S, Viney R, et al. Health-related quality of life amongst primary caregivers of children with intellectual disability. J Intellect Disabil Res. 2020;64(2):103–16.PubMedCrossRef
31.
Majoni M, Oremus M. Does being a retired or employed caregiver affect the association between behaviours in Alzheimer’s disease and caregivers’ health-related quality-of-life? BMC Res Notes. 2017;10(1):766.PubMedPubMedCentralCrossRef
32.
Reed C, Barrett A, Lebrec J, et al. How useful is the EQ-5D in assessing the impact of caring for people with Alzheimer’s disease? Health Qual Life Outcomes. 2017;15(1):16.PubMedPubMedCentralCrossRef
33.
Soare IA, Flint I, Savic N, et al. Quality of life study for caregivers of people with uncontrolled focal-onset seizures. J Med Econ. 2022;25(1):66–76.PubMedCrossRef
34.
Valcárcel-Nazco C, Ramallo-Fariña Y, Linertová R, et al. Health-related quality of life and perceived burden of informal caregivers of patients with rare diseases in selected European countries. Int J Environ Res Public Health. 2022;19(13):8208.
35.
Li C, Yuan J, Huang X, et al. Correlation between depression and intimacy in lung cancer patients and their family caregivers. BMC Palliat Care. 2022;21(1):99.PubMedPubMedCentralCrossRef
36.
Seo YJ, Park H. Factors influencing caregiver burden in families of hospitalised patients with lung cancer. J Clin Nurs. 2019;28(9–10):1979–89.PubMedCrossRef
37.
Geng HM, Chuang DM, Yang F, et al. Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(39):e11863.PubMedCrossRef
38.
Fekete C, Tough H, Siegrist J, et al. Health impact of objective burden, subjective burden and positive aspects of caregiving: an observational study among caregivers in Switzerland. BMJ Open. 2017;7(12):e017369.PubMedPubMedCentralCrossRef
39.
Northouse L, Williams AL, Given B, et al. Psychosocial care for family caregivers of patients with cancer. J Clin Oncol. 2012;30(11):1227–34.PubMedCrossRef
40.
Schulte T, Schniewind B, Walter J, et al. Age-related impairment of quality of life after lung resection for non-small cell lung cancer. Lung Cancer. 2010;68(1):115–20.PubMedCrossRef
41.
Collins LG, Haines C, Perkel R, et al. Lung cancer: diagnosis and management. Am Fam Phys. 2007;75(1):56–63.
42.
Yuan G, Zhan C, Huang Y, et al. Clinical characteristics and prognosis of basaloid squamous cell carcinoma of the lung: a population-based analysis. PeerJ. 2019;7:e6724.PubMedPubMedCentralCrossRef
43.
Hiel L, Beenackers MA, Renders CM, et al. Providing personal informal care to older European adults: should we care about the caregivers’ health? Prev Med. 2015;70:64–8.PubMedCrossRef
44.
Belasco AG, Sesso R. Burden and quality of life of caregivers for hemodialysis patients. Am J Kidney Dis. 2002;39(4):805–12.PubMedCrossRef
45.
Haley WE, Levine EG, Brown SL, et al. Psychological, social, and health consequences of caring for a relative with senile dementia. J Am Geriatr Soc. 1987;35(5):405–11.PubMedCrossRef
46.
Milbury K, Badr H, Fossella F, et al. Longitudinal associations between caregiver burden and patient and spouse distress in couples coping with lung cancer. Support Care Cancer. 2013;21(9):2371–9.PubMedPubMedCentralCrossRef
47.
Carmack Taylor C L, Badr H, Lee J H, et al. Lung cancer patients and their spouses: psychological and relationship functioning within 1 month of treatment initiation. Ann Behav Med. 2008;36(2):129–40.
Metadata
Title
Does caring for patients with advanced non-small cell lung cancer affect health-related quality of life of caregivers? A multicenter, cross-sectional study
Authors
Yi Yang
Liu Liu
Jia Chen
Yuying Gan
Chunxia Su
Haibo Zhang
Enwu Long
Fei Yan
Yingyao Chen
Publication date
01-12-2024
Publisher
BioMed Central
Keywords
NSCLC
NSCLC
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-17669-w

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