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01-02-2022 | NSCLC | Original Article

Clinical research on the combined use of systemic chemotherapy and CT-guided radiofrequency ablation in treatment of lung cancer

Authors: Feng Xu, Zhigang Cai, Beizheng Xu, Jian Song, Haiyan Liu, Xuanmei Li, Aibing Deng, Xiaotang Wu, Jun Chen

Published in: Lasers in Medical Science | Issue 1/2022

Abstract

The purpose of this study is to describe the clinical efficacy and safety of the combined use of systemic chemotherapy and CT-guided radiofrequency ablation (RFA) in treatment of lung cancer. A panel of 256 patients with lung cancer who were admitted to our hospital from June 2017 to October 2019 were recruited. According to the treatment plan, the patients were divided into test group (n = 128) and control group (n = 128). Patients in the test group were treated by systemic chemotherapy combined with CT-guided RFA, while patients in the control group were given systemic chemotherapy only. After treatment, a comparative analysis was conducted in terms of clinical efficacy, level of tumor markers, and adverse reactions. Meanwhile, patients in the two groups were followed up for analysis of progression-free survival (PFS) and overall survival (OS). After treatment, the tumor objective response rate and disease control rate of patients in the test group were significantly higher than those in the control group. Besides, in patients of the test group, tumor markers, such as serum carcino-embryonic antigen, neuro-specific enolase, cytokeratin-19, and carbohydrate antigen-199, presented a remarkably lower level relative to those in the control group (p < 0.05). However, there was no significant difference observed with regard to the incidence of complications (p > 0.05). Additionally, patients in the test group were more likely to have better PFS and OS. Notably, we monitored that in the test group, superior clinical efficacy was achieved in patients with non-small cell lung cancer and lung adenocarcinoma relative to that in patients with small cell lung cancer and lung squamous cell carcinoma, respectively. The combined use of systemic chemotherapy and CT-guided RFA can produce good clinical efficacy in treatment of lung cancer. It is relatively safe and deserves promotion and application in clinic.

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Title: Clinical research on the combined use of systemic chemotherapy and CT-guided radiofrequency ablation in treatment of lung cancer
Authors: Feng Xu
Zhigang Cai
Beizheng Xu
Jian Song
Haiyan Liu
Xuanmei Li
Aibing Deng
Xiaotang Wu
Jun Chen
Publication date: 01-02-2022
Publisher: Springer London
Keywords: NSCLC
Lung Cancer
Lung Cancer
Cancer Biomarker
NSCLC
SCLC
Lung Cancer
SCLC
Cytostatic Therapy
Published in: Lasers in Medical Science / Issue 1/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03222-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical research on the combined use of systemic chemotherapy and CT-guided radiofrequency ablation in treatment of lung cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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