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Surgery Today
Published in: Surgery Today 9/2023

Open Access 08-02-2023 | NSCLC | Original Article

Comparable efficacy and safety of COVID-19 vaccines for patients receiving tegafur–uracil as postoperative adjuvant chemotherapy

Authors: Megumi Nishikubo, Yugo Tanaka, Suguru Mitsui, Takefumi Doi, Daisuke Hokka, Wataru Hojo, Hironori Sakai, Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Hironobu Minami, Yoshimasa Maniwa

Published in: Surgery Today | Issue 9/2023

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Abstract

Purpose

Many effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but a weaker response in individuals undergoing anticancer treatment has been reported. This study evaluates the immunogenic status and safety of SARS-CoV-2 vaccines for patients with non-small-cell lung cancer (NSCLC), receiving tegafur–uracil (UFT) as postoperative adjuvant chemotherapy.

Methods

The subjects of this prospective study were 40 patients who underwent surgery for NSCLC and received SARS-CoV-2 vaccines postoperatively. We compared the antibody titers of SARS-CoV-2 vaccines and the adverse events between patients who received adjuvant UFT and patients who did not.

Results

The mean anti-S1 IgG titers were not significantly different between the UFT and without-UFT groups (mean optimal density, 0.194 vs. 0.205; P = 0.76). Multivariate analysis identified the period after the second vaccination as an independent predictor of anti-S1 IgG titer (P = 0.049), but not the UFT status (with or without-UFT treatment; P = 0.47). The prevalence of adverse events did not differ significantly between the groups, and no severe adverse events occurred.

Conclusions

The efficacy and safety of the SARS-CoV-2 vaccines for NSCLC patients who received postoperative adjuvant UFT chemotherapy were comparable to those for NSCLC patients who did not receive postoperative adjuvant UFT chemotherapy.

Clinical trial registration

This study was registered with the University Hospital Medical Information Network (UMIN) in Japan (UMIN000047380).
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Metadata
Title
Comparable efficacy and safety of COVID-19 vaccines for patients receiving tegafur–uracil as postoperative adjuvant chemotherapy
Authors
Megumi Nishikubo
Yugo Tanaka
Suguru Mitsui
Takefumi Doi
Daisuke Hokka
Wataru Hojo
Hironori Sakai
Yohei Funakoshi
Kimikazu Yakushijin
Goh Ohji
Hironobu Minami
Yoshimasa Maniwa
Publication date
08-02-2023
Publisher
Springer Nature Singapore
Published in
Surgery Today / Issue 9/2023
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-023-02649-1

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