Published in:
01-12-2017 | Invited Commentary
Novel Pathways and Potential Therapeutic Strategies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): CD123 and Beyond
Author:
Naveen Pemmaraju
Published in:
Current Hematologic Malignancy Reports
|
Issue 6/2017
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Excerpt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a historically rare hematologic malignancy with poor overall outcomes, a challenging pathologic and clinical presentation, and no consensus therapeutic approach [
1]. After decades of changing nomenclature (e.g., CD4+CD56+ hematodermic tumor, blastic NK cell lymphoma), the WHO ultimately solidified the name “BPDCN” and placed it under “Acute myeloid leukemia (AML) and related family of neoplasms” in 2008 [
2]. With increasing understanding of BPDCN, further recognition of its distinct clinical presentation and course, and evolving molecular insights, the disease has now been designated as its own separate category under myeloid malignancies in the latest WHO re-classification schema [
3]. …