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Respiratory Research
Published in: Respiratory Research 1/2016

Open Access 01-12-2016 | Review

Novel biomarkers for pulmonary arterial hypertension

Authors: Anjum Anwar, Gregoire Ruffenach, Aman Mahajan, Mansoureh Eghbali, Soban Umar

Published in: Respiratory Research | Issue 1/2016

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Abstract

Pulmonary arterial hypertension is a deadly disease characterized by elevated pulmonary arterial pressures leading to right ventricular hypertrophy and failure. The confirmatory gold standard test is the invasive right heart catheterization. The disease course is monitored by pulmonary artery systolic pressure measurement via transthoracic echocardiography. A simple non-invasive test to frequently monitor the patients is much needed. Search for a novel biomarker that can be detected by a simple test is ongoing and many different options are being studied. Here we review some of the new and unique pre-clinical options for potential pulmonary hypertension biomarkers. These biomarkers can be broadly categorized based on their association with endothelial cell dysfunction, inflammation, epigenetics, cardiac function, oxidative stress, metabolism,extracellular matrix, and volatile compounds in exhaled breath condensate. A biomarker that can be detected in blood, urine or breath condensate and correlates with disease severity, progression and response to therapy may result in significant cost reduction and improved patient outcomes.
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Metadata
Title
Novel biomarkers for pulmonary arterial hypertension
Authors
Anjum Anwar
Gregoire Ruffenach
Aman Mahajan
Mansoureh Eghbali
Soban Umar
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-016-0396-6

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