Published in:
01-09-2018 | Drug-Induced Liver Injury (NP Chalasani and MS Ghabril, Section Editors)
Novel Approaches to Causality Adjudication in Drug-Induced Liver Disease
Published in: Current Hepatology Reports | Issue 3/2018
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Purpose of Review
Drug-induced liver injury (DILI) is a complex diagnosis dominantly based of exclusion.
Recent Findings
Currently available causality assessment instruments are considered to be suboptimal. Expert opinion appears to be best method to adjudicate causality, but is impractical to implement on a wide scale basis. Thus, new approaches are needed, for example, improving the specificity of current scoring systems. A further option would be to develop a system that utilizes computer-based scoring—which would reduce human error. Additionally, it would be ideal to have available drug-specific scoring systems, based on drugs’ characteristic “phenotypes” (presentation and pattern of injury). Eventually, a validated system could be integrated within electronic health information systems.
Summary
This review highlights an avenue to an improved causality assessment tool.