Note of clarification regarding data about the association between the interleukin-1β −31T>C polymorphism and breast cancer risk

Excerpt

Recently, we read with great interest a paper entitled “Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis”, which was published online in Breast Cancer Research and Treatment 124: 821–825, 2010 [1]. In this paper, Liu et al. performed a meta-analysis to examine the association between the interleukin-1beta (IL-1β) −31T>C (rs1143627) polymorphism and breast cancer risk based on four studies including 1543 cases and 1165 controls [1]. Their results indicated that the variant CC genotype of rs1143627 was associated with a significantly increased breast cancer risk (CC versus TT: odds ratio (OR) = 1.37, 95 % confidence interval (CI) 1.10–1.70, P = 0.22 for heterogeneity; CC versus TT/TC: OR = 1.40, 95 % CI 1.17–1.67, P = 0.49 for heterogeneity) [1]. It is an interesting study. …