Skip to main content
Top
Published in: Malaria Journal 1/2005

Open Access 01-12-2005 | Case report

Nosocomial Plasmodium falciparum infections confirmed by molecular typing in Medellín, Colombia

Authors: Lina González, Jesus Ochoa, Liliana Franco, Marta Arroyave, Eliana Restrepo, Silvia Blair, Amanda Maestre

Published in: Malaria Journal | Issue 1/2005

Login to get access

Abstract

Three cases of nosocomial malaria are reported from patients of the Internal Medicine Ward of a tertiary University teaching hospital in Medellin, Colombia. Epidemiological research, based on entomological captures, medical records review and interviews of nursery staff about patient care practices potentially involving contact with blood, were carried out. Molecular characterization of Plasmodium falciparum was based on the amplification of MSP1, MSP2 and GLURP genes. This method enabled confirmation of the same P. falciparum genotype in all three patients as well as in a fourth one (index case). The presence of nosocomial malaria was confirmed and it was concluded that the most likely source of transmission was through multi-dose preparations of heparin applied to heparin locks.
Appendix
Available only for authorised users
Literature
1.
go back to reference Farnert A, Arez AP, Babiker HA, Beck HP, Benito A, Bjorkman A, Bruce MC, Conway DJ, Day KP, Henning L, Mercereau-Puijalon O, Ranford-Cartwright LC, Rubio JM, Snounou G, Walliker D, Zwetyenga J, Do Rosario VE: Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study. Trans R Soc Trop Med Hyg. 2001, 95: 225-232. 10.1016/S0035-9203(01)90175-0.CrossRefPubMed Farnert A, Arez AP, Babiker HA, Beck HP, Benito A, Bjorkman A, Bruce MC, Conway DJ, Day KP, Henning L, Mercereau-Puijalon O, Ranford-Cartwright LC, Rubio JM, Snounou G, Walliker D, Zwetyenga J, Do Rosario VE: Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study. Trans R Soc Trop Med Hyg. 2001, 95: 225-232. 10.1016/S0035-9203(01)90175-0.CrossRefPubMed
2.
go back to reference Blair S, Lopez ML, Pineros JG, Alvarez T, Tobon A, Carmona J: Eficacia terapéutica de tres esquemas de tratamiento de malaria no complicada por Plasmodiumfalciparum en Antioquia 2002. Biomedica. 2003, 23: 318-327.CrossRefPubMed Blair S, Lopez ML, Pineros JG, Alvarez T, Tobon A, Carmona J: Eficacia terapéutica de tres esquemas de tratamiento de malaria no complicada por Plasmodiumfalciparum en Antioquia 2002. Biomedica. 2003, 23: 318-327.CrossRefPubMed
3.
go back to reference Al-Saigul AM, Fontaine RE, Haddad Q: Nosocomial malaria from contamination of a multidose heparin container with blood. Infect Control Hosp Epidemiol. 2000, 21: 329-330.CrossRefPubMed Al-Saigul AM, Fontaine RE, Haddad Q: Nosocomial malaria from contamination of a multidose heparin container with blood. Infect Control Hosp Epidemiol. 2000, 21: 329-330.CrossRefPubMed
4.
go back to reference Kirchgatter K, Wunderlich G, Branquinho MS, Salles TM, Lian YC, Carneiro-Junior RA, Di Santi SM: Molecular typing of Plasmodium falciparum from Giemsa-stained blood smears confirms nosocomial malaria transmission. Acta Trop. 2002, 84: 199-203. 10.1016/S0001-706X(02)00181-X.CrossRefPubMed Kirchgatter K, Wunderlich G, Branquinho MS, Salles TM, Lian YC, Carneiro-Junior RA, Di Santi SM: Molecular typing of Plasmodium falciparum from Giemsa-stained blood smears confirms nosocomial malaria transmission. Acta Trop. 2002, 84: 199-203. 10.1016/S0001-706X(02)00181-X.CrossRefPubMed
5.
go back to reference Montoya L, Maestre A, Carmona J, Lopes D, Do Rosario V, Blair S: Plasmodium falciparum : diversity studies of isolates from two Colombian regions with different endemicity. Exp Parasitol. 2003, 104: 14-19. 10.1016/S0014-4894(03)00112-7.CrossRefPubMed Montoya L, Maestre A, Carmona J, Lopes D, Do Rosario V, Blair S: Plasmodium falciparum : diversity studies of isolates from two Colombian regions with different endemicity. Exp Parasitol. 2003, 104: 14-19. 10.1016/S0014-4894(03)00112-7.CrossRefPubMed
6.
go back to reference Viriyakosol S, Siripoon N, Petcharapirat C, Petcharapirat P, Jarra W, Thaithong S, Brown KN, Snounou G: Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bull World Health Organ. 1995, 73: 85-95.PubMedCentralPubMed Viriyakosol S, Siripoon N, Petcharapirat C, Petcharapirat P, Jarra W, Thaithong S, Brown KN, Snounou G: Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bull World Health Organ. 1995, 73: 85-95.PubMedCentralPubMed
Metadata
Title
Nosocomial Plasmodium falciparum infections confirmed by molecular typing in Medellín, Colombia
Authors
Lina González
Jesus Ochoa
Liliana Franco
Marta Arroyave
Eliana Restrepo
Silvia Blair
Amanda Maestre
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2005
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-4-9

Other articles of this Issue 1/2005

Malaria Journal 1/2005 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.