Published in:
01-11-2016 | Research Letter
Nonspecific binding of a frequently used vitamin D receptor (VDR) antibody: important implications for vitamin D research in human health
Authors:
Pedro L. F. Costa, Monica M. França, Bruno Ferraz-de-Souza
Published in:
Endocrine
|
Issue 2/2016
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Excerpt
Amid the ongoing debate surrounding optimal vitamin D status for bone and mineral homeostasis, the investigation of extraskeletal effects of vitamin D on several aspects of human health has burgeoned in recent years [
1‐
4]. Indeed, a variety of potentially beneficial actions of vitamin D have been proposed, including in areas of major public health concerns such as cancer and cardiovascular disease [
5‐
7]. Besides the cumulative epidemiological evidence linking serum 25-hydroxyvitamin levels to extraskeletal outcomes, biological plausibility of these pleiotropic effects has derived from the identification of the vitamin D receptor (VDR) in numerous cells and tissues beyond those directly involved in bone metabolism [
8,
9]. …
