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30-04-2022 | Non-ST-Segment Elevation Myocardial Infarction | Management of Acute Coronary Syndromes (H Jneid, Section Editor)

Readmission After ACS: Burden, Epidemiology, and Mitigation

Authors: Peter K. Boulos, John C. Messenger, Stephen W. Waldo

Published in: Current Cardiology Reports | Issue 7/2022

Abstract

Purpose of Review

The past decade has brought increased efforts to better understand causes for ACS readmissions and strategies to minimize them. This review seeks to provide a critical appraisal of this rapidly growing body of literature.

Recent Findings

Prior to 2010, readmission rates for patients suffering from ACS remained relatively constant. More recently, several strategies have been implemented to mitigate this including improved risk assessment models, transition care bundles, and development of targeted programs by federal organizations and professional societies. These strategies have been associated with a significant reduction in ACS readmission rates in more recent years. With this, improvements in 30-day post-discharge mortality rates are also being appreciated. As we continue to expand our knowledge on independent risk factors for ACS readmissions, further strategies targeting at-risk populations may further decrease the rate of readmissions.

Summary

Efforts to understand and reduce 30-day ACS readmission rates have resulted in overall improved quality of care for patients.

Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, et al. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association. Circulation. 2021;143(8):e254–743. https://doi.org/10.1161/CIR.0000000000000950.CrossRefPubMed

HCUP National Inpatient Sample (NIS). In: (HCUP) HCaUP, editor. Rockville, MD: Agency for Healthcare Research and Quality. 2018.

Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med. 2009;360(14):1418–28. https://doi.org/10.1056/NEJMsa0803563.CrossRefPubMed

Krumholz HM, Merrill AR, Schone EM, Schreiner GC, Chen J, Bradley EH, et al. Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission. Circ Cardiovasc Qual Outcomes. 2009;2(5):407–13. https://doi.org/10.1161/CIRCOUTCOMES.109.883256.CrossRefPubMed

• Kwok CS, Capers Q, Savage M, Gulati M, Potts J, Mohamed MO, et al. Unplanned hospital readmissions after acute myocardial infarction: a nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014. Coron Artery Dis. 2020;31(4):354–64. https://doi.org/10.1097/MCA.0000000000000844. This study provides a comprehensive review on the burden, epidemiology, and impact of ACS readmissions utilizing a large NRD dataset that allows for improved external validity.CrossRefPubMed

Axon RN, Williams MV. Hospital readmission as an accountability measure. JAMA. 2011;305(5):504–5. https://doi.org/10.1001/jama.2011.72.CrossRefPubMed

Psotka MA, Fonarow GC, Allen LA, Joynt Maddox KE, Fiuzat M, Heidenreich P, et al. The Hospital Readmissions Reduction Program: Nationwide Perspectives and Recommendations: A JACC: Heart Failure Position Paper. JACC Heart Fail. 2020;8(1):1–11. https://doi.org/10.1016/j.jchf.2019.07.012.CrossRefPubMed

Boccuti C, Casillas G. Aiming for fewer hospital u-turns: the Medicare hospital readmission reduction program. Issue brief. Menlo Park, CA: Henry J. Kaiser Family Foundation 2017.

Khera R, Krumholz HM. Effects of the Hospital Readmissions Reduction Program. Circ Cardiovasc Qual Outcomes. 2018;11(12): e005083. https://doi.org/10.1161/CIRCOUTCOMES.118.005083.CrossRefPubMed

10.

Tisminetzky M, McManus DD, Erskine N, Saczynski JS, Yarzebski J, Granillo E, et al. Thirty-day hospital readmissions in patients with non-ST-segment elevation acute myocardial infarction. Am J Med. 2015;128(7):760–5. https://doi.org/10.1016/j.amjmed.2015.01.022.CrossRefPubMedPubMedCentral

11.

Dunlay SM, Weston SA, Killian JM, Bell MR, Jaffe AS, Roger VL. Thirty-day rehospitalizations after acute myocardial infarction: a cohort study. Ann Intern Med. 2012;157(1):11–8. https://doi.org/10.7326/0003-4819-157-1-201207030-00004.CrossRefPubMedPubMedCentral

12.

Bernheim SM, Grady JN, Lin Z, Wang Y, Savage SV, Bhat KR, et al. National patterns of risk-standardized mortality and readmission for acute myocardial infarction and heart failure. Update on publicly reported outcomes measures based on the 2010 release. Circ Cardiovasc Qual Outcomes. 2010;3(5):459–67. https://doi.org/10.1161/CIRCOUTCOMES.110.957613.

13.

Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA. 2013;309(4):355–63. https://doi.org/10.1001/jama.2012.216476.CrossRefPubMedPubMedCentral

14.

Krumholz HM, Normand ST, Wang Y. Twenty-year trends in outcomes for older adults with acute myocardial infarction in the United States. JAMA Netw Open. 2019;2(3): e191938. https://doi.org/10.1001/jamanetworkopen.2019.1938.CrossRefPubMedPubMedCentral

15.

Khera R, Krumholz HM. With great power comes great responsibility: big data research from the National Inpatient Sample. Circ Cardiovasc Qual Outcomes. 2017;10(7). https://doi.org/10.1161/CIRCOUTCOMES.117.003846.

16.

Suter LG, Li SX, Grady JN, Lin Z, Wang Y, Bhat KR, et al. National patterns of risk-standardized mortality and readmission after hospitalization for acute myocardial infarction, heart failure, and pneumonia: update on publicly reported outcomes measures based on the 2013 release. J Gen Intern Med. 2014;29(10):1333–40. https://doi.org/10.1007/s11606-014-2862-5.CrossRefPubMedPubMedCentral

17.

Chen HY, Tisminetzky M, Yarzebski J, Gore JM, Goldberg RJ. Decade-long trends in the frequency of 90-day rehospitalizations after hospital discharge for acute myocardial infarction. Am J Cardiol. 2016;117(5):743–8. https://doi.org/10.1016/j.amjcard.2015.12.006.CrossRefPubMed

18.

Wasfy JH, Zigler CM, Choirat C, Wang Y, Dominici F, Yeh RW. Readmission rates after passage of the Hospital Readmissions Reduction Program: a pre-post analysis. Ann Intern Med. 2017;166(5):324–31. https://doi.org/10.7326/M16-0185.CrossRefPubMed

19.

Zuckerman RB, Sheingold SH, Orav EJ, Ruhter J, Epstein AM. Readmissions, observation, and the Hospital Readmissions Reduction Program. N Engl J Med. 2016;374(16):1543–51. https://doi.org/10.1056/NEJMsa1513024.CrossRefPubMed

20.

Khera R, Wang Y, Bernheim SM, Lin Z, Krumholz HM. Post-discharge acute care and outcomes following readmission reduction initiatives: national retrospective cohort study of Medicare beneficiaries in the United States. BMJ. 2020;368: l6831. https://doi.org/10.1136/bmj.l6831.CrossRefPubMedPubMedCentral

21.

Wadhera RK, Joynt Maddox KE, Kazi DS, Shen C, Yeh RW. Hospital revisits within 30 days after discharge for medical conditions targeted by the Hospital Readmissions Reduction Program in the United States: national retrospective analysis. BMJ. 2019;366: l4563. https://doi.org/10.1136/bmj.l4563.CrossRefPubMedPubMedCentral

22.

Angraal S, Khera R, Zhou S, Wang Y, Lin Z, Dharmarajan K, et al. Trends in 30-day readmission rates for Medicare and non-Medicare patients in the era of the Affordable Care Act. Am J Med. 2018;131(11):1324-31.e14. https://doi.org/10.1016/j.amjmed.2018.06.013.CrossRefPubMedPubMedCentral

23.

Khera R, Jain S, Pandey A, Agusala V, Kumbhani DJ, Das SR, et al. Comparison of readmission rates after acute myocardial infarction in 3 patient age groups (18 to 44, 45 to 64, and ≥65 years) in the United States. Am J Cardiol. 2017;120(10):1761–7. https://doi.org/10.1016/j.amjcard.2017.07.081.CrossRefPubMedPubMedCentral

24.

Cruz Rodriguez J, Acharya P, Olson E, Cler L. Risk factors for 30-day readmissions after acute myocardial infarction. International Cardiovascular Forum Journal. 2015;4:30. https://doi.org/10.17987/icfj.v4i0.155.CrossRef

25.

Sukul D, Sinha SS, Ryan AM, Sjoding MW, Hummel SL, Nallamothu BK. Patterns of readmissions for three common conditions among younger US adults. Am J Med. 2017;130(10):1220.e1–.e16. https://doi.org/10.1016/j.amjmed.2017.05.025.

26.

Dreyer RP, Ranasinghe I, Wang Y, Dharmarajan K, Murugiah K, Nuti SV, et al. Sex differences in the rate, timing, and principal diagnoses of 30-day readmissions in younger patients with acute myocardial infarction. Circulation. 2015;132(3):158–66. https://doi.org/10.1161/CIRCULATIONAHA.114.014776.CrossRefPubMedPubMedCentral

27.

O’Brien C, Valsdottir L, Wasfy JH, Strom JB, Secemsky EA, Wang Y, et al. Comparison of 30-day readmission rates after hospitalization for acute myocardial infarction in men versus women. Am J Cardiol. 2017;120(7):1070–6. https://doi.org/10.1016/j.amjcard.2017.06.046.CrossRefPubMed

28.

Mahmoud AN, Elgendy IY. Gender impact on 30-day readmissions after hospitalization with acute myocardial infarction complicated by cardiogenic shock (from the 2013 to 2014 National Readmissions Database). Am J Cardiol. 2018;121(5):523–8. https://doi.org/10.1016/j.amjcard.2017.11.023.CrossRefPubMed

29.

Anand SS, Xie CC, Mehta S, Franzosi MG, Joyner C, Chrolavicius S, et al. Differences in the management and prognosis of women and men who suffer from acute coronary syndromes. J Am Coll Cardiol. 2005;46(10):1845–51. https://doi.org/10.1016/j.jacc.2005.05.091.CrossRefPubMed

30.

Joynt KE, Orav EJ, Jha AK. Thirty-day readmission rates for Medicare beneficiaries by race and site of care. JAMA. 2011;305(7):675–81. https://doi.org/10.1001/jama.2011.123.CrossRefPubMedPubMedCentral

31.

Pandey A, Keshvani N, Khera R, Lu D, Vaduganathan M, Joynt Maddox KE, et al. Temporal trends in racial differences in 30-day readmission and mortality rates after acute myocardial infarction among Medicare beneficiaries. JAMA Cardiol. 2020;5(2):136–45. https://doi.org/10.1001/jamacardio.2019.4845.CrossRefPubMedPubMedCentral

32.

Rodriguez F, Joynt KE, López L, Saldaña F, Jha AK. Readmission rates for Hispanic Medicare beneficiaries with heart failure and acute myocardial infarction. Am Heart J. 2011;162(2):254-61.e3. https://doi.org/10.1016/j.ahj.2011.05.009.CrossRefPubMed

33.

Chaiyachati KH, Qi M, Werner RM. Changes to racial disparities in readmission rates after Medicare’s Hospital Readmissions Reduction Program within safety-net and non-safety-net hospitals. JAMA Netw Open. 2018;1(7): e184154. https://doi.org/10.1001/jamanetworkopen.2018.4154.CrossRefPubMedPubMedCentral

34.

Sonel AF, Good CB, Mulgund J, Roe MT, Gibler WB, Smith SC, et al. Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?). Circulation. 2005;111(10):1225–32. https://doi.org/10.1161/01.CIR.0000157732.03358.64.CrossRefPubMed

35.

Lipstein SH, Dunagan WC. The risks of not adjusting performance measures for sociodemographic factors. Ann Intern Med. 2014;161(8):594–6. https://doi.org/10.7326/M14-1601.CrossRefPubMed

36.

Joynt KE, Zuckerman R, Epstein AM. Social risk factors and performance under Medicare’s value-based purchasing programs. Circ Cardiovasc Qual Outcomes. 2017;10(5). https://doi.org/10.1161/CIRCOUTCOMES.117.003587.

37.

Bernheim SM, Parzynski CS, Horwitz L, Lin Z, Araas MJ, Ross JS, et al. Accounting for patients’ socioeconomic status does not change hospital readmission rates. Health Aff (Millwood). 2016;35(8):1461–70. https://doi.org/10.1377/hlthaff.2015.0394.CrossRef

38.

Kind AJ, Jencks S, Brock J, Yu M, Bartels C, Ehlenbach W, et al. Neighborhood socioeconomic disadvantage and 30-day rehospitalization: a retrospective cohort study. Ann Intern Med. 2014;161(11):765–74. https://doi.org/10.7326/M13-2946.CrossRefPubMedPubMedCentral

39.

Joynt Maddox KE, Reidhead M, Hu J, Kind AJH, Zaslavsky AM, Nagasako EM, et al. Adjusting for social risk factors impacts performance and penalties in the hospital readmissions reduction program. Health Serv Res. 2019;54(2):327–36. https://doi.org/10.1111/1475-6773.13133.CrossRefPubMedPubMedCentral

40.

Joynt KE, Jha AK. Characteristics of hospitals receiving penalties under the Hospital Readmissions Reduction Program. JAMA. 2013;309(4):342–3. https://doi.org/10.1001/jama.2012.94856.CrossRefPubMed

41.

Gilman M, Hockenberry JM, Adams EK, Milstein AS, Wilson IB, Becker ER. The financial effect of value-based purchasing and the Hospital Readmissions Reduction Program on safety-net hospitals in 2014: a cohort study. Ann Intern Med. 2015;163(6):427–36. https://doi.org/10.7326/M14-2813.CrossRefPubMed

42.

Roberts ET, Zaslavsky AM, Barnett ML, Landon BE, Ding L, McWilliams JM. Assessment of the effect of adjustment for patient characteristics on hospital readmission rates: implications for pay for performance. JAMA Intern Med. 2018;178(11):1498–507. https://doi.org/10.1001/jamainternmed.2018.4481.CrossRefPubMedPubMedCentral

43.

McCarthy CP, Vaduganathan M, Patel KV, Lalani HS, Ayers C, Bhatt DL, et al. Association of the new peer group-stratified method with the reclassification of penalty status in the Hospital Readmission Reduction Program. JAMA Netw Open. 2019;2(4): e192987. https://doi.org/10.1001/jamanetworkopen.2019.2987.CrossRefPubMedPubMedCentral

44.

Kim LK, Yeo I, Cheung JW, Swaminathan RV, Wong SC, Charitakis K, et al. Thirty-day readmission rates, timing, causes, and costs after ST-segment-elevation myocardial infarction in the United States: a National Readmission Database analysis 2010–2014. J Am Heart Assoc. 2018;7(18): e009863. https://doi.org/10.1161/JAHA.118.009863.CrossRefPubMedPubMedCentral

45.

Jang SJ, Yeo I, Feldman DN, Cheung JW, Minutello RM, Singh HS, et al. Associations between hospital length of stay, 30-day readmission, and costs in ST-segment-elevation myocardial infarction after primary percutaneous coronary intervention: a Nationwide Readmissions Database analysis. J Am Heart Assoc. 2020;9(11): e015503. https://doi.org/10.1161/JAHA.119.015503.CrossRefPubMedPubMedCentral

46.

Labrosciano C, Tavella R, Air T, Zeitz CJ, Worthley M, Beltrame JF. The LACE Index: a predictor of mortality and readmission in patients with acute myocardial infarction. J Healthc Qual. 2021;43(5):292–303. https://doi.org/10.1097/JHQ.0000000000000296.CrossRefPubMed

47.

Shah M, Patil S, Patel B, Agarwal M, Davila CD, Garg L, et al. Causes and predictors of 30-day readmission in patients with acute myocardial infarction and cardiogenic shock. Circ Heart Fail. 2018;11(4): e004310. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004310.CrossRefPubMed

48.

Mahmoud AN, Elgendy IY, Mojadidi MK, Wayangankar SA, Bavry AA, Anderson RD, et al. Prevalence, causes, and predictors of 30-day readmissions following hospitalization with acute myocardial infarction complicated by cardiogenic shock: findings from the 2013–2014 National Readmissions Database. J Am Heart Assoc. 2018;7(6). https://doi.org/10.1161/JAHA.117.008235.

49.

Sud K, Haddadin F, Tsutsui RS, Parashar A, Bandyopadhyay D, Ellis SG, et al. Readmissions in ST-elevation myocardial infarction and cardiogenic shock (from Nationwide Readmission Database). Am J Cardiol. 2019;124(12):1841–50. https://doi.org/10.1016/j.amjcard.2019.08.048.CrossRefPubMed

50.

Culler SD, Kugelmass AD, Cohen DJ, Reynolds MR, Katz MR, Brown PP, et al. Understanding readmissions in Medicare beneficiaries during the 90-day follow-up period of an acute myocardial infarction admission. J Am Heart Assoc. 2019;8(21): e013513. https://doi.org/10.1161/JAHA.119.013513.CrossRefPubMedPubMedCentral

51.

Sreenivasan J, Abu-Haniyeh A, Hooda U, Khan MS, Aronow WS, Michos ED, et al. Rate, causes, and predictors of 90-day readmissions and the association with index hospitalization coronary revascularization following non-ST elevation myocardial infarction in the United States. Catheter Cardiovasc Interv. 2021;98(1):12–21. https://doi.org/10.1002/ccd.29119.CrossRefPubMed

52.

Martin LM, Januzzi JL, Thompson RW, Ferris TG, Singh JP, Bhambhani V, et al. Clinical profile of acute myocardial infarction patients included in the Hospital Readmissions Reduction Program. J Am Heart Assoc. 2018;7(16): e009339. https://doi.org/10.1161/JAHA.118.009339.CrossRefPubMedPubMedCentral

53.

McCarthy C, Murphy S, Cohen JA, Rehman S, Jones-O’Connor M, Olshan DS, et al. Misclassification of myocardial injury as myocardial infarction: implications for assessing outcomes in value-based programs. JAMA Cardiol. 2019;4(5):460–4. https://doi.org/10.1001/jamacardio.2019.0716.

54.

Desai NR, Ross JS, Kwon JY, Herrin J, Dharmarajan K, Bernheim SM, et al. Association between hospital penalty status under the Hospital Readmission Reduction Program and readmission rates for target and nontarget conditions. JAMA. 2016;316(24):2647–56. https://doi.org/10.1001/jama.2016.18533.CrossRefPubMedPubMedCentral

55.

Southern DA, Ngo J, Martin BJ, Galbraith PD, Knudtson ML, Ghali WA, et al. Characterizing types of readmission after acute coronary syndrome hospitalization: implications for quality reporting. J Am Heart Assoc. 2014;3(5): e001046. https://doi.org/10.1161/JAHA.114.001046.CrossRefPubMedPubMedCentral

56.

Khot UN, Johnson MJ, Wiggins NB, Lowry AM, Rajeswaran J, Kapadia S, et al. Long-term time-varying risk of readmission after acute myocardial infarction. J Am Heart Assoc. 2018;7(21): e009650. https://doi.org/10.1161/JAHA.118.009650.CrossRefPubMedPubMedCentral

57.

Hegeman TW, Glorioso TJ, Hess E, Barón AE, Ho PM, Maddox TM, et al. Facility-level percutaneous coronary intervention readmission rates are not associated with facility-level mortality: insights from the VA Clinical Assessment, Reporting, and Tracking (CART) Program. J Am Heart Assoc. 2016;5(9). https://doi.org/10.1161/JAHA.116.003503.

58.

Kwok CS, Shah B, Al-Suwaidi J, Fischman DL, Holmvang L, Alraies C, et al. Timing and causes of unplanned readmissions after percutaneous coronary intervention: insights from the Nationwide Readmission Database. JACC Cardiovasc Interv. 2019;12(8):734–48. https://doi.org/10.1016/j.jcin.2019.02.007.CrossRefPubMedPubMedCentral

59.

Kwok CS, Rao SV, Potts JE, Kontopantelis E, Rashid M, Kinnaird T, et al. Burden of 30-day readmissions after percutaneous coronary intervention in 833,344 patients in the United States: predictors, causes, and cost: insights from the Nationwide Readmission Database. JACC Cardiovasc Interv. 2018;11(7):665–74. https://doi.org/10.1016/j.jcin.2018.01.248.CrossRefPubMed

60.

Wasfy JH, Rosenfield K, Zelevinsky K, Sakhuja R, Lovett A, Spertus JA, et al. A prediction model to identify patients at high risk for 30-day readmission after percutaneous coronary intervention. Circ Cardiovasc Qual Outcomes. 2013;6(4):429–35. https://doi.org/10.1161/CIRCOUTCOMES.111.000093.CrossRefPubMed

61.

Wasfy JH, Strom JB, O’Brien C, Zai AH, Luttrell J, Kennedy KF, et al. Causes of short-term readmission after percutaneous coronary intervention. Circ Cardiovasc Interv. 2014;7(1):97–103. https://doi.org/10.1161/CIRCINTERVENTIONS.113.000988.CrossRefPubMed

62.

Wasfy JH, Strom JB, Waldo SW, O’Brien C, Wimmer NJ, Zai AH, et al. Clinical preventability of 30-day readmission after percutaneous coronary intervention. J Am Heart Assoc. 2014;3(5): e001290. https://doi.org/10.1161/JAHA.114.001290.CrossRefPubMedPubMedCentral

63.

Kini V, Peterson PN, Spertus JA, Kennedy KF, Arnold SV, Wasfy JH, et al. Clinical model to predict 90-day risk of readmission after acute myocardial infarction. Circ Cardiovasc Qual Outcomes. 2018;11(10): e004788. https://doi.org/10.1161/CIRCOUTCOMES.118.004788.CrossRefPubMedPubMedCentral

64.

Smith LN, Makam AN, Darden D, Mayo H, Das SR, Halm EA, et al. Acute myocardial infarction readmission risk prediction models: a systematic review of model performance. Circ Cardiovasc Qual Outcomes. 2018;11(1): e003885. https://doi.org/10.1161/CIRCOUTCOMES.117.003885.CrossRefPubMedPubMedCentral

65.

Van Grootven B, Jepma P, Rijpkema C, Verweij L, Leeflang M, Daams J, et al. Prediction models for hospital readmissions in patients with heart disease: a systematic review and meta-analysis. BMJ Open. 2021;11(8): e047576. https://doi.org/10.1136/bmjopen-2020-047576.CrossRefPubMedPubMedCentral

66.

Raposeiras-Roubín S, Abu-Assi E, Cambeiro-González C, Álvarez-Álvarez B, Pereira-López E, Gestal-Romaní S, et al. Mortality and cardiovascular morbidity within 30 days of discharge following acute coronary syndrome in a contemporary European cohort of patients: how can early risk prediction be improved? The six-month GRACE risk score. Rev Port Cardiol. 2015;34(6):383–91. https://doi.org/10.1016/j.repc.2014.11.020.CrossRefPubMed

67.

Matheny ME, Ricket I, Goodrich CA, Shah RU, Stabler ME, Perkins AM, et al. Development of electronic health record-based prediction models for 30-day readmission risk among patients hospitalized for acute myocardial infarction. JAMA Netw Open. 2021;4(1): e2035782. https://doi.org/10.1001/jamanetworkopen.2020.35782.CrossRefPubMedPubMedCentral

68.

Koehler BE, Richter KM, Youngblood L, Cohen BA, Prengler ID, Cheng D, et al. Reduction of 30-day postdischarge hospital readmission or emergency department (ED) visit rates in high-risk elderly medical patients through delivery of a targeted care bundle. J Hosp Med. 2009;4(4):211–8. https://doi.org/10.1002/jhm.427.CrossRefPubMed

69.

Coleman EA, Parry C, Chalmers S, Min SJ. The care transitions intervention: results of a randomized controlled trial. Arch Intern Med. 2006;166(17):1822–8. https://doi.org/10.1001/archinte.166.17.1822.CrossRefPubMed

70.

Jack BW, Chetty VK, Anthony D, Greenwald JL, Sanchez GM, Johnson AE, et al. A reengineered hospital discharge program to decrease rehospitalization: a randomized trial. Ann Intern Med. 2009;150(3):178–87. https://doi.org/10.7326/0003-4819-150-3-200902030-00007.CrossRefPubMedPubMedCentral

71.

Bradley EH, Curry L, Horwitz LI, Sipsma H, Wang Y, Walsh MN, et al. Hospital strategies associated with 30-day readmission rates for patients with heart failure. Circ Cardiovasc Qual Outcomes. 2013;6(4):444–50. https://doi.org/10.1161/CIRCOUTCOMES.111.000101.CrossRefPubMedPubMedCentral

72.

Tung YC, Chang GM, Chang HY, Yu TH. Relationship between early physician follow-up and 30-day readmission after acute myocardial infarction and heart failure. PLoS ONE. 2017;12(1): e0170061. https://doi.org/10.1371/journal.pone.0170061.CrossRefPubMedPubMedCentral

73.

Marbach JA, Johnson D, Kloo J, Vira A, Keith S, Kraft WK, et al. The impact of a transition of care program on acute myocardial infarction readmission rates. Am J Med Qual. 2018;33(5):481–6. https://doi.org/10.1177/1062860618754702.CrossRefPubMed

74.

Bhandare D, Shimshak T. Acute myocardial readmission reduction program: “never discharge a patient.” Journal of Cardiology and Cardiovascular Sciences. 2020;4:17–21. https://doi.org/10.29245/2578-3025/2020/2.1196.CrossRef

75.

Bradley EH, Curry L, Horwitz LI, Sipsma H, Thompson JW, Elma M, et al. Contemporary evidence about hospital strategies for reducing 30-day readmissions: a national study. J Am Coll Cardiol. 2012;60(7):607–14. https://doi.org/10.1016/j.jacc.2012.03.067.CrossRefPubMedPubMedCentral

76.

Wu CM, Albert NM, Gluckman TJ, Lu D, Rogers S, Mobayed J, et al. Facilitating the identification of patients hospitalized for acute myocardial infarction and heart failure and the assessment of their readmission risk through the Patient Navigator Program. Am Heart J. 2020;224:77–84. https://doi.org/10.1016/j.ahj.2020.03.020.CrossRefPubMed

77.

Ryan AM, Krinsky S, Adler-Milstein J, Damberg CL, Maurer KA, Hollingsworth JM. Association between hospitals’ engagement in value-based reforms and readmission reduction in the Hospital Readmission Reduction Program. JAMA Intern Med. 2017;177(6):862–8. https://doi.org/10.1001/jamainternmed.2017.0518.CrossRefPubMedPubMedCentral

78.

Dunlay SM, Pack QR, Thomas RJ, Killian JM, Roger VL. Participation in cardiac rehabilitation, readmissions, and death after acute myocardial infarction. Am J Med. 2014;127(6):538–46. https://doi.org/10.1016/j.amjmed.2014.02.008.CrossRefPubMedPubMedCentral

79.

• Wasfy JH, Hidrue MK, Ngo J, Tanguturi VK, Cafiero-Fonseca ET, Thompson RW, et al. Association of an acute myocardial infarction readmission-reduction program with mortality and readmission. Circ Cardiovasc Qual Outcomes. 2020;13(5): e006043. https://doi.org/10.1161/CIRCOUTCOMES.119.006043. This study provides a practical and impactful real-world approach to reducing ACS readmissions.CrossRefPubMedPubMedCentral

80.

Tanguturi VK, Temin E, Yeh RW, Thompson RW, Rao SK, Mallick A, et al. Clinical interventions to reduce preventable hospital readmission after percutaneous coronary intervention. Circ Cardiovasc Qual Outcomes. 2016;9(5):600–4. https://doi.org/10.1161/CIRCOUTCOMES.116.003086.CrossRefPubMed

81.

Gupta A, Fonarow GC. The Hospital Readmissions Reduction Program: evidence for harm. JACC Heart Fail. 2018;6(7):607–9. https://doi.org/10.1016/j.jchf.2018.02.012.CrossRefPubMed

82.

Gupta A, Fonarow GC. The Hospital Readmissions Reduction Program-learning from failure of a healthcare policy. Eur J Heart Fail. 2018;20(8):1169–74. https://doi.org/10.1002/ejhf.1212.CrossRefPubMed

83.

Ashton CM, Kuykendall DH, Johnson ML, Wray NP, Wu L. The association between the quality of inpatient care and early readmission. Ann Intern Med. 1995;122(6):415–21. https://doi.org/10.7326/0003-4819-122-6-199503150-00003.CrossRefPubMed

84.

Pandey A, Golwala H, Hall HM, Wang TY, Lu D, Xian Y, et al. Association of US centers for Medicare and Medicaid services hospital 30-day risk-standardized readmission metric with care quality and outcomes after acute myocardial infarction: findings from the National Cardiovascular Data Registry/Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines. JAMA Cardiol. 2017;2(7):723–31. https://doi.org/10.1001/jamacardio.2017.1143.CrossRefPubMedPubMedCentral

85.

Joynt KE, Jha AK. A path forward on Medicare readmissions. N Engl J Med. 2013;368(13):1175–7. https://doi.org/10.1056/NEJMp1300122.CrossRefPubMed

86.

Joynt KE, Jha AK. Thirty-day readmissions–truth and consequences. N Engl J Med. 2012;366(15):1366–9. https://doi.org/10.1056/NEJMp1201598.CrossRefPubMed

87.

Gorodeski EZ, Starling RC, Blackstone EH. Are all readmissions bad readmissions? N Engl J Med. 2010;363(3):297–8. https://doi.org/10.1056/NEJMc1001882.CrossRefPubMed

88.

Ashton CM, Del Junco DJ, Souchek J, Wray NP, Mansyur CL. The association between the quality of inpatient care and early readmission: a meta-analysis of the evidence. Med Care. 1997;35(10):1044–59. https://doi.org/10.1097/00005650-199710000-00006.CrossRefPubMed

89.

Jneid H, Addison D, Bhatt DL, Fonarow GC, Gokak S, Grady KL, et al. 2017 AHA/ACC clinical performance and quality measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circ Cardiovasc Qual Outcomes. 2017;10(10). https://doi.org/10.1161/HCQ.0000000000000032.

90.

Khera R, Wang Y, Nasir K, Lin Z, Krumholz HM. Evaluation of 30-day hospital readmission and mortality rates using regression-discontinuity framework. J Am Coll Cardiol. 2019;74(2):219–34. https://doi.org/10.1016/j.jacc.2019.04.060.CrossRefPubMedPubMedCentral

91.

Khera R, Dharmarajan K, Wang Y, Lin Z, Bernheim SM, Normand ST, et al. Association of the Hospital Readmissions Reduction Program with mortality during and after hospitalization for acute myocardial infarction, heart failure, and pneumonia. JAMA Netw Open. 2018;1(5): e182777. https://doi.org/10.1001/jamanetworkopen.2018.2777.CrossRefPubMedPubMedCentral

92.

Chatterjee P, Joynt Maddox KE. US national trends in mortality from acute myocardial infarction and heart failure: policy success or failure? JAMA Cardiol. 2018;3(4):336–40. https://doi.org/10.1001/jamacardio.2018.0218.CrossRefPubMedPubMedCentral

93.

Dharmarajan K, Wang Y, Lin Z, Normand ST, Ross JS, Horwitz LI, et al. Association of changing hospital readmission rates with mortality rates after hospital discharge. JAMA. 2017;318(3):270–8. https://doi.org/10.1001/jama.2017.8444.CrossRefPubMedPubMedCentral

94.

Wadhera RK, Joynt Maddox KE, Wasfy JH, Haneuse S, Shen C, Yeh RW. Association of the Hospital Readmissions Reduction Program with mortality among Medicare beneficiaries hospitalized for heart failure, acute myocardial infarction, and pneumonia. JAMA. 2018;320(24):2542–52. https://doi.org/10.1001/jama.2018.19232.CrossRefPubMedPubMedCentral

Title: Readmission After ACS: Burden, Epidemiology, and Mitigation
Authors: Peter K. Boulos
John C. Messenger
Stephen W. Waldo
Publication date: 30-04-2022
Publisher: Springer US
Keywords: Non-ST-Segment Elevation Myocardial Infarction
ST-Segment Elevation Myocardial Infarction
Acute Coronary Syndrome
Published in: Current Cardiology Reports / Issue 7/2022
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-022-01702-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Readmission After ACS: Burden, Epidemiology, and Mitigation

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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