Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2007

Open Access 01-12-2007 | Case report

Non-Hodgkin's lymphoma of the sphenoid sinus presenting as isolated oculomotor nerve palsy

Authors: Young Mok Park, Jun Hyung Cho, Jae Yong Cho, Ji Soon Huh, Jung Yong Ahn

Published in: World Journal of Surgical Oncology | Issue 1/2007

Login to get access

Abstract

Background

Solitary involvement of the sphenoid sinus has rarely been reported in non-Hodgkin's lymphoma. Isolated oculomotor nerve palsy is uncommon as an initial presentation of malignant tumors of the sphenoid sinus.

Case presentation

A 53-year-old woman presented with a three-month history of headache and diplopia. Neurological examination revealed complete left oculomotor nerve palsy. Magnetic Resonance Imaging (MRI) demonstrated a homogenous soft-tissue lesion occupying the left sphenoid sinus and invading the left cavernous sinus. The patient underwent transsphenoidal biopsy and the lesion was histologically diagnosed as non-Hodgkin's lymphoma, diffuse large B-cell type. Tumor cells were positive for CD20 and negative for CD3. Following six cycles of chemotherapy, the left oculomotor nerve palsy that had been previously observed was completely resolved. There was no enhancing lesion noted on follow-up MRI.

Conclusion

It is important to recognize that non-Hodgkin's lymphoma of the sphenoid sinus can present with isolated oculomotor nerve palsy, although it is extremely rare. The cranial nerve deficits can resolve dramatically after chemotherapy.
Appendix
Available only for authorised users
Literature
1.
Freeman C, Berg JW, Cutler SJ: Occurrence and prognosis of extranodal lymphomas. Cancer. 1972, 29: 252-260. 10.1002/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#.CrossRefPubMed
2.
Reddy S, Pellettiere E, Saxena V, Hendrickson FR: Extranodal non-Hodgkin's lymphoma. Cancer. 1980, 46: 1925-1931. 10.1002/1097-0142(19801101)46:9<1925::AID-CNCR2820460906>3.0.CO;2-4.CrossRefPubMed
3.
Rudders RA, Ross ME, DeLellis RA: Primary extranodal lymphoma. Response to treatment and factors influencing prognosis. Cancer. 1978, 42: 406-416. 10.1002/1097-0142(197808)42:2<406::AID-CNCR2820420205>3.0.CO;2-H.CrossRefPubMed
4.
Frierson HF, Mills SE, Innes DJ: Non-Hodgkin's lymphomas of the sinonasal region: Histologic subtypes and their clinicopathologic features. Am J Clin Pathol. 1984, 81: 721-727.PubMed
5.
Deleu D, Lagopoulos M, Moundhry MA, Katchy K: Isolated bilateral abducens nerve palsy in primary sphenoidal sinus non-Hodgkin lymphoma. Acta Neurol Belg. 2000, 100: 103-106.PubMed
6.
Ferrario F, Roselli R, Piantanida R, Boschini P, Maffioli M: Primary lymphoma of the sphenoid sinus. Report of a case and review of the literature. Ann Otolaryngol Chir Cervicofac. 1995, 112: 298-302.PubMed
7.
Metellus P, Fuentes S, Figarella-Branger D, Dufour H, Grisoli F: Sphenoid sinus lymphoma. Case report and review of the literature. Neurochirurgie. 2002, 48: 522-526.PubMed
8.
Roth DB, Siatkowski RM: Bilateral blindness as the initial presentation of lymphoma of the sphenoid sinus. Am J Ophthalmol. 2000, 129: 256-258. 10.1016/S0002-9394(99)00308-6.CrossRefPubMed
9.
Ueba T, Miyatake S, Hashimoto N, Kikuchi H: Primary malignant lymphoma in the sphenoid sinus with orbital apex syndrome: a case report. No Shinkei Geka. 1992, 20: 283-287.PubMed
10.
Weber AL, Loewenheim H: Lymphoma of the sphenoid sinus presenting as an expansile mass. Ann Otol Rhinol Laryngol. 1993, 102: 318-321.CrossRefPubMed
11.
Lawson W, Reino AJ: Isolated sphenoid sinus disease: an analysis of 132 cases. Laryngoscope. 1997, 107: 1590-1595. 10.1097/00005537-199712000-00003.CrossRefPubMed
12.
Som PM, Shapiro MD, Biller HF, Sasaki C, Lawson W: Sinonasal tumours and inflammatory tissues: differentiation with MR imaging. Radiology. 1988, 167: 803-808.CrossRefPubMed
13.
DeMonte F, Ginsberg LE, Clayman GL: Primary malignant tumors of the sphenoid sinus. Neurosurgery. 2000, 46: 1084-1092. 10.1097/00006123-200005000-00012.CrossRefPubMed
14.
Esposito F, Kelly DF, Vinters HV, DeSalles AA, Sercarz J, Gorgulhos AA: Primary sphenoid sinus neoplasms: a report of four cases with common clinical presentation treated with transsphenoidal surgery and adjuvant therapies. J Neurooncol. 2006, 76: 299-306. 10.1007/s11060-005-7285-z.CrossRefPubMed
15.
Sethi DS: Isolated sphenoid lesions: diagnosis and management. Otolaryngol Head Neck Surg. 1999, 120: 730-736. 10.1053/hn.1999.v120.a89436.CrossRefPubMed
16.
Abbondanzo SL, Wenig BM: Non-Hodgkin's lymphoma of the sinonasal tract: a clinicopathologic and immunophenotypic study of 120 cases. Cancer. 1995, 75: 1281-1291. 10.1002/1097-0142(19950315)75:6<1281::AID-CNCR2820750610>3.0.CO;2-I.CrossRefPubMed
17.
Tran LM, Mark R, Fu YS, Calcaterra T, Juillard G: Primary non-Hodgkin's lymphoma of the paranasal sinuses and nasal cavity. A report of 18 cases with state IE disease. Am J Clin Oncol. 1992, 15: 222-225. 10.1097/00000421-199206000-00008.CrossRefPubMed
18.
Nakamura K, Uehara S, Omagari J, Kunitake N, Kimura M, Makino Y, Ishigami K, Masuda K: Primary non-Hodgkin lymphoma of the sinonasal cavities: correlation of CT evaluation with clinical outcome. Radiology. 1997, 204: 431-435.CrossRefPubMed
19.
Jacobs C, Hoppe RT: Non-Hodgkin's lymphomas of head and neck extranodal sites. Int J Radiat Oncol Biol Phys. 1985, 11: 357-364.CrossRefPubMed
20.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M: Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: A review. Cancer Treat Rev. 2003, 29: 11-19. 10.1016/S0305-7372(02)00094-4.CrossRefPubMed
21.
Coiffier B, Lepage E, Briere J: CHOP Chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. N Engl J Med. 2002, 346: 235-242. 10.1056/NEJMoa011795.CrossRefPubMed
Metadata
Title
Non-Hodgkin's lymphoma of the sphenoid sinus presenting as isolated oculomotor nerve palsy
Authors
Young Mok Park
Jun Hyung Cho
Jae Yong Cho
Ji Soon Huh
Jung Yong Ahn
Publication date
01-12-2007
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2007
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-5-86

Other articles of this Issue 1/2007

World Journal of Surgical Oncology 1/2007 Go to the issue

Technical innovations

Stereotaxic gamma knife surgery in treatment of critically located pilocytic astrocytoma: preliminary result

Research

FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA

Case report

Combined endocrine and exocrine tumours of the pancreas

Case report

Late aortic lymphocele and residual ovary syndrome after gynecological surgery

Case report

Faecal incontinence as presentation of an ependymomas of the spinal cord

Case report

A rare case of primary mesenteric gastrointestinal stromal tumor with metastasis to the cervix uteri