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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 3/2013

01-09-2013 | Metabolic Complications and Comorbidity (JM Kilby, Section Editor)

Non-AIDS-defining Cancers Among HIV-Infected Patients

Authors: James Cutrell, Roger Bedimo

Published in: Current HIV/AIDS Reports | Issue 3/2013

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Abstract

In the highly active antiretroviral therapy (HAART) era, the incidence of non-AIDS-defining cancers (NADC) has increased and contributes to a growing proportion of mortality in the aging HIV-infected population. The underlying pathogenic mechanisms of increased cancer risk are incompletely understood. Potential contributors include oncogenic effects of the HIV virus, immunosuppression, chronic inflammation and immune activation, exposure to HAART, higher rates of oncogenic viral coinfections and traditional cancer risk factors. HIV-infected patients often present with NADC at younger ages with more aggressive or advanced stage disease. However, when standard cancer therapy is given, treatment outcomes appear similar to the non-HIV population. These facts highlight the importance of clinicians’ maintaining a high index of suspicion, performing age-appropriate screening, and optimizing cancer therapy. Development of novel strategies for screening, prevention, and treatment of NADC will be required to reverse these epidemiologic trends and improve the survival of HIV-infected patients.
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Metadata
Title
Non-AIDS-defining Cancers Among HIV-Infected Patients
Authors
James Cutrell
Roger Bedimo
Publication date
01-09-2013
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 3/2013
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-013-0166-8

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