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Published in: Breast Cancer Research and Treatment 1/2011

01-02-2011 | Brief Report

No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women

Authors: Jonathan Beesley, Sharon E. Johnatty, Xiaoqing Chen, Amanda B. Spurdle, Paolo Peterlongo, Monica Barile, Valeria Pensotti, Siranoush Manoukian, Paolo Radice, Georgia Chenevix-Trench, Australian Ovarian Cancer Study Group, Kathleen Cuningham Consortium for Research in Familial Breast Cancer

Published in: Breast Cancer Research and Treatment | Issue 1/2011

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Abstract

ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorphism (SNP) encoding an amino acid change has recently been shown to determine whether cerumen (earwax) is wet or dry. We hypothesised that this ABCC11 SNP may be associated with breast cancer risk because an association has been reported between wet earwax and increased risk of breast cancer. We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk.
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Metadata
Title
No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women
Authors
Jonathan Beesley
Sharon E. Johnatty
Xiaoqing Chen
Amanda B. Spurdle
Paolo Peterlongo
Monica Barile
Valeria Pensotti
Siranoush Manoukian
Paolo Radice
Georgia Chenevix-Trench
Australian Ovarian Cancer Study Group
Kathleen Cuningham Consortium for Research in Familial Breast Cancer
Publication date
01-02-2011
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2011
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-010-1292-2

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