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01-05-2016 | Neurology and Preclinical Neurological Studies - Short communication

Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI

Authors: Daniela Frosini, Roberto Ceravolo, Michela Tosetti, Ubaldo Bonuccelli, Mirco Cosottini

Published in: Journal of Neural Transmission | Issue 5/2016

Abstract

Ten healthy subjects (HS) and 15 patients with atypical parkinsonisms underwent 7-T susceptibility-weighted-imaging MR to evaluate substantia nigra (SN). All HS were judged “normal”. Twelve out of 15 patients exhibited bilateral abnormal SN while three patients with corticobasal degeneration (CBD) showed bilateral normal aspect of SN. Anatomical changes of SN at 7 T occur in multiple system atrophy and progressive supranuclear palsy as previously reported in Parkinson’s disease. Preserved SN in CBD confirms the pathological heterogeneity of this disease.

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Title: Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI
Authors: Daniela Frosini
Roberto Ceravolo
Michela Tosetti
Ubaldo Bonuccelli
Mirco Cosottini
Publication date: 01-05-2016
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 5/2016
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1529-2

At a glance: The STEP trials

Springer Medicine

Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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