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Inflammopharmacology
Published in: Inflammopharmacology 4/2018

01-08-2018 | Original Article

New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy

Authors: Neveen A. Salem, Marwa El-Shamarka, Yasser Khadrawy, Shaimaa El-Shebiney

Published in: Inflammopharmacology | Issue 4/2018

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Abstract

Temporal lobe epilepsy (TLE) is present in 30% of epileptic patients and does not respond to conventional treatments. Bone marrow derived mesenchymal stem cells (BMSCs) induce endogenous neural stem cells, inhibit neurodegeneration, and promote brain self-repair mechanisms. The present study addresses the feasibility of BMSCs transplantation against pilocarpine-induced TLE experimentally. BMSCs were injected either intravenously (IV) or in hippocampus bilaterally (IC). Increased cell count of BMSCs was achieved via IC route. BMSCs treatment ameliorated the pilocarpine-induced neurochemical and histological changes, retained amino acid neurotransmitters to the normal level, downregulated the immunoreactivity to insulin growth factor-1 receptor, synaptophysin, and caspase-3 and reduced oxidative insult and inflammatory markers detected in epileptic model. It is worth noting that BMSCs IC-administered showed more pronounced effects than those administered via IV route. BMSCs transplantation presents a promise for TLE treatment that has to be elucidated clinically.
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Metadata
Title
New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy
Authors
Neveen A. Salem
Marwa El-Shamarka
Yasser Khadrawy
Shaimaa El-Shebiney
Publication date
01-08-2018
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 4/2018
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-018-0456-2

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