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01-01-2018 | Original Paper

New phenanthrene and 9, 10-dihydrophenanthrene derivatives from the stems of Dendrobium officinale with their cytotoxic activities

Authors: Gui-Yun Zhao, Bo-Wen Deng, Chong-Yu Zhang, Yi-Da Cui, Jia-Yi Bi, Guo-Gang Zhang

Published in: Journal of Natural Medicines | Issue 1/2018

Abstract

Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1–2) with six known congeners (3–8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC₅₀ values of 11.96 and 8.92 μM.

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Title: New phenanthrene and 9, 10-dihydrophenanthrene derivatives from the stems of Dendrobium officinale with their cytotoxic activities
Authors: Gui-Yun Zhao
Bo-Wen Deng
Chong-Yu Zhang
Yi-Da Cui
Jia-Yi Bi
Guo-Gang Zhang
Publication date: 01-01-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1141-2

At a glance: The STEP trials

Springer Medicine

New phenanthrene and 9, 10-dihydrophenanthrene derivatives from the stems of Dendrobium officinale with their cytotoxic activities

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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