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01-01-2018 | Original Paper

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Authors: Hiroshi Yamashita, Keiko Takeda, Machiko Haraguchi, Yuki Abe, Natsumi Kuwahara, Shota Suzuki, Ayaka Terui, Takumi Masaka, Naoko Munakata, Mariko Uchida, Masashi Nunokawa, Kyousuke Kaneda, Masuo Goto, Kuo-Hsiung Lee, Koji Wada

Published in: Journal of Natural Medicines | Issue 1/2018

Abstract

Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several diterpenoid alkaloid constituents of Aconitum and Delphinium plants as well as their derivatives exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vincristine-resistant nasopharyngeal cancer cell lines. Four new C₁₉-diterpenoid alkaloids, 14-anisoyllasianine (1), 14-anisoyl-N-deethylaconine (2), N-deethylaljesaconitine A (3), and N-deethylnevadensine (4), together with 17 known C₁₉- and C₂₀-diterpenoid alkaloids, were isolated in a phytochemical investigation of rhizoma of Aconitum japonicum Thunb. subsp. subcuneatum (Nakai) Kadota. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Eight known diterpenoid alkaloids, lipoaconitine, lipomesaconitine, aconine, nevadenine, talatisamine, nevadensine, ryosenamine, and dehydrolucidusculine, were isolated the first time from A. japonicum subsp. subcuneatum. Three of the new C₁₉-diterpenoid alkaloids (1, 3, 4) and six of the known diterpenoid alkaloids were evaluated for cytotoxic activity against five human tumor cell lines.

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Title: Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum
Authors: Hiroshi Yamashita
Keiko Takeda
Machiko Haraguchi
Yuki Abe
Natsumi Kuwahara
Shota Suzuki
Ayaka Terui
Takumi Masaka
Naoko Munakata
Mariko Uchida
Masashi Nunokawa
Kyousuke Kaneda
Masuo Goto
Kuo-Hsiung Lee
Koji Wada
Publication date: 01-01-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1139-9

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Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Abstract

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Abstract

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