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01-12-2008 | Magnetic Resonance

New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma

Authors: Qiang Yue, Tomonori Isobe, Yasushi Shibata, Izumi Anno, Hiraku Kawamura, Youhei Yamamoto, Shingo Takano, Akira Matsumura

Published in: European Radiology | Issue 12/2008

Abstract

This study was aimed to clarify some ambiguities in the interpretation of proton magnetic resonance spectroscopy (1H-MRS) of meningiomas. The cases of 31 meningioma patients (27 benign and 4 nonbenign meningiomas) that underwent single-voxel 1H-MRS (PRESS sequence, TR/TE = 2,000 ms/68, 136, 272 ms) were retrospectively analyzed. To verify the findings of in-vivo study, phantoms were measured, and pathological sections of 11 patients were reviewed. All meningiomas demonstrated increased choline and decreased creatine, except for a lipomatous meningioma that only displayed a prominent lipid (Lip) peak. Alanine (Ala) and lactate (Lac) coexisted in eight cases, indicating an alternative pathway of energy metabolism in meningiomas. They partially overlapped with each other and demonstrated a triplet-like spectral pattern, which was consistent with phantom study. Glutamine/glutamate (Glx) was helpful for the recognition of meningioma when Ala was absent. N-acetyl compounds(NACs) were observed in nine cases whose voxels were completely limited within the tumors, indicating that meningiomas might have endogenous NACs. Lac was indicative of an aggressive meningioma, although not always a nonbenign one. Lip not only represented micronecrosis in nonbenign meningiomas, but also reflected microcystic changes or fatty degeneration in benign meningiomas. 1H-MRS reflects some distinctive biochemical and pathological changes of meningiomas that might be misinterpreted.

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Title: New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma
Authors: Qiang Yue
Tomonori Isobe
Yasushi Shibata
Izumi Anno
Hiraku Kawamura
Youhei Yamamoto
Shingo Takano
Akira Matsumura
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 12/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-1079-6

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New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma

Abstract

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