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Published in: Neuroradiology 2/2007

01-02-2007 | Diagnostic Neuroradiology

Utilization of glutamate/creatine ratios for proton spectroscopic diagnosis of meningiomas

Authors: Saman Hazany, John R. Hesselink, John F. Healy, Steven G. Imbesi

Published in: Neuroradiology | Issue 2/2007

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Abstract

Introduction

Our purpose was to determine the potential of metabolites other than alanine to diagnose intracranial meningiomas on proton magnetic resonance spectroscopy (MRS).

Methods

Using a 1.5-T MR system the lesions were initially identified on FLAIR, and T1- and T2-weighted images. Employing standard point-resolved spectroscopy (PRESS) for single voxel proton MRS (TR 1500 ms, TE 30 ms, 128 acquisitions, voxel size 2 × 2 × 2 cm, acquisition time 3.12 min), MR spectra were obtained from 5 patients with meningiomas, from 20 with other intracranial lesions, and from 4 normal controls. Peak heights of nine resonances, including lipid, lactate, alanine, NAA (N-acetylaspartate), β/γ-Glx (glutamate + glutamine), creatine, choline, myo-inositol, and α-Glx/glutathione, were measured in all spectra. The relative quantity of each metabolite was measured as the ratio of its peak height to the peak height of creatine.

Results

Relative quantities of α-Glx/glutathione, β/γ-Glx, and total Glx/glutathione were significantly elevated in meningiomas compared to the 20 other intracranial lesions and the normal control brains. Alanine was found in four of five meningiomas, but lactate partially masked the alanine in three meningiomas. None of the other lesions or control brains showed an alanine peak. The one meningioma with no alanine and the three others with lactate had elevated Glx.

Conclusion

While alanine is a relatively unique marker for meningioma, our results support the hypothesis that the combination of glutamate/creatine ratios and alanine on proton MRS is more specific and reliable for the diagnosis of meningiomas than alanine alone.
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Metadata
Title
Utilization of glutamate/creatine ratios for proton spectroscopic diagnosis of meningiomas
Authors
Saman Hazany
John R. Hesselink
John F. Healy
Steven G. Imbesi
Publication date
01-02-2007
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 2/2007
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-006-0167-z

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