Skip to main content
Top
Published in: Critical Care 6/2004

01-12-2004 | Commentary

New indications for the use of therapeutic hypothermia

Author: Stephen Bernard

Published in: Critical Care | Issue 6/2004

Login to get access

Abstract

Randomised, controlled trials of therapeutic hypothermia have demonstrated improved outcomes after out-of-hospital cardiac arrest, where the initial cardiac rhythm was ventricular fibrillation. This therapy is now endorsed by the International Liaison Committee on Resuscitation. The role of therapeutic hypothermia in patients with anoxic neurological injury due to stroke, spinal cord injury or asphyxial cardiac arrest is uncertain. However, given the strong theoretical benefit and the minimal adverse side-effects, it is reasonable for clinicians to consider the use of therapeutic hypothermia in such cases.
Literature
1.
2.
go back to reference Bernard SA: Induced hypothermia in intensive care medicine: a review. Anaesth Intensive Care 1996, 24: 382-388.PubMed Bernard SA: Induced hypothermia in intensive care medicine: a review. Anaesth Intensive Care 1996, 24: 382-388.PubMed
3.
go back to reference Sterz F, Safar P, Tisherman S, Radovsky A, Kuboyama K, Oku K: Mild hypothermic cardiopulmonary resuscitation improves outcome after cardiac arrest in dogs. Crit Care Med 1991, 19: 379-389.CrossRefPubMed Sterz F, Safar P, Tisherman S, Radovsky A, Kuboyama K, Oku K: Mild hypothermic cardiopulmonary resuscitation improves outcome after cardiac arrest in dogs. Crit Care Med 1991, 19: 379-389.CrossRefPubMed
4.
go back to reference Bernard SA, Jones BM, Buist M: Experience with prolonged induced hypothermia in patients with severe head injury. Crit Care 1999, 3: 167-172. 10.1186/cc371PubMedCentralCrossRefPubMed Bernard SA, Jones BM, Buist M: Experience with prolonged induced hypothermia in patients with severe head injury. Crit Care 1999, 3: 167-172. 10.1186/cc371PubMedCentralCrossRefPubMed
5.
go back to reference Bernard SA, Jones BM, Horne MK: A clinical trial of induced hypothermia in comatose survivors of prehospital cardiac arrest. Ann Emerg Med 1997, 30: 146-153.CrossRefPubMed Bernard SA, Jones BM, Horne MK: A clinical trial of induced hypothermia in comatose survivors of prehospital cardiac arrest. Ann Emerg Med 1997, 30: 146-153.CrossRefPubMed
6.
go back to reference Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346: 557-563. 10.1056/NEJMoa003289CrossRefPubMed Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346: 557-563. 10.1056/NEJMoa003289CrossRefPubMed
7.
go back to reference Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346: 549-556. 10.1056/NEJMoa012689CrossRef Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346: 549-556. 10.1056/NEJMoa012689CrossRef
8.
go back to reference Nolan JP, Morley PT, Hoek TL, Hickey RW, Advancement Life support Task Force of the International Liaison committee on Resuscitation: Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life Support Task Force of the International Liaison Committee on Resuscitation. Resuscitation 2003, 57: 231-235. 10.1016/S0300-9572(03)00184-9CrossRefPubMed Nolan JP, Morley PT, Hoek TL, Hickey RW, Advancement Life support Task Force of the International Liaison committee on Resuscitation: Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life Support Task Force of the International Liaison Committee on Resuscitation. Resuscitation 2003, 57: 231-235. 10.1016/S0300-9572(03)00184-9CrossRefPubMed
9.
go back to reference Hartemink KJ, Wisselink W, Rauwerda JA, Girges ARJ, Polderman KH: Novel applications of therapeutic hypothermia: report of three cases. Crit Care 2004, 8: R336-R342. 10.1186/cc2928CrossRef Hartemink KJ, Wisselink W, Rauwerda JA, Girges ARJ, Polderman KH: Novel applications of therapeutic hypothermia: report of three cases. Crit Care 2004, 8: R336-R342. 10.1186/cc2928CrossRef
10.
go back to reference Bernard SA, Buist MD: Induced hypothermia in the intensive care unit: a review. Crit Care Med 2003, 31: 2041-2051. 10.1097/01.CCM.0000069731.18472.61CrossRefPubMed Bernard SA, Buist MD: Induced hypothermia in the intensive care unit: a review. Crit Care Med 2003, 31: 2041-2051. 10.1097/01.CCM.0000069731.18472.61CrossRefPubMed
11.
go back to reference Katz LM, Young A, Frank JE, Wang Y, Park K: Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia. Crit Care Med 2004, 32: 806-810. 10.1097/01.CCM.0000114998.00860.FDCrossRefPubMed Katz LM, Young A, Frank JE, Wang Y, Park K: Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia. Crit Care Med 2004, 32: 806-810. 10.1097/01.CCM.0000114998.00860.FDCrossRefPubMed
12.
go back to reference Bernard SA, Buist MD, Monteiro O, Smith K: Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 2003, 56: 9-13. 10.1016/S0300-9572(02)00276-9CrossRefPubMed Bernard SA, Buist MD, Monteiro O, Smith K: Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 2003, 56: 9-13. 10.1016/S0300-9572(02)00276-9CrossRefPubMed
Metadata
Title
New indications for the use of therapeutic hypothermia
Author
Stephen Bernard
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2004
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2994

Other articles of this Issue 6/2004

Critical Care 6/2004 Go to the issue