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Archives of Virology
Published in: Archives of Virology 5/2009

01-05-2009 | Original Article

Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions

Authors: Tomomi Takano, Natsuko Azuma, Miyuki Satoh, Ayako Toda, Yoshikiyo Hashida, Ryoichi Satoh, Tsutomu Hohdatsu

Published in: Archives of Virology | Issue 5/2009

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Abstract

Feline infectious peritonitis (FIP) is a feline coronavirus (FCoV)-induced fatal disease of domestic and wild cats. The infiltration of neutrophils into granulomatous lesions is unusual for a viral disease, but it is a typical finding of FIP. This study aimed to investigate the reason for the lesions containing neutrophils in cats with FIP. Neutrophils of cats with FIP were cultured, and changes in the cell survival rate were assessed. In addition, the presence or absence of neutrophil survival factors was investigated in specimens collected from cats with FIP. Furthermore, it was investigated whether macrophages, one of the target cells of FIPV infection, produce neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF). We showed that virus-infected macrophages overproduce neutrophil survival factors, and these factors act on neutrophils and up-regulate their survival. These observations suggest that sustained production of neutrophil survival factors by macrophages during FCoV infection is sufficient for neutrophil survival and contributes to development of granulomatous lesions.
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Metadata
Title
Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions
Authors
Tomomi Takano
Natsuko Azuma
Miyuki Satoh
Ayako Toda
Yoshikiyo Hashida
Ryoichi Satoh
Tsutomu Hohdatsu
Publication date
01-05-2009
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 5/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0371-3

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