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Inflammation
Published in: Inflammation 1/2014

01-02-2014

Neuropeptide Downregulation in Sepsis

Authors: Fabiano Pinheiro da Silva, Marcel Cerqueira César Machado, Paulo Clemente Sallet, Fernando Godinho Zampieri, Alessandra Carvalho Goulart, Francisco Torggler Filho, Hermes Vieira Barbeiro, Irineu Tadeu Velasco, Luiz Monteiro da Cruz Neto, Heraldo Possolo de Souza

Published in: Inflammation | Issue 1/2014

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Abstract

Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammatory signaling, and many others. The effects of neuropeptides in the pathophysiology of sepsis, however, remain poorly investigated. A prospective cohort study to investigate the effects of neuropeptides in sepsis was carried out. Here, we describe that neuropeptides are downregulated during septic shock. We propose that it may be a protective mechanism of the host to avoid further inflammatory injury.
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Metadata
Title
Neuropeptide Downregulation in Sepsis
Authors
Fabiano Pinheiro da Silva
Marcel Cerqueira César Machado
Paulo Clemente Sallet
Fernando Godinho Zampieri
Alessandra Carvalho Goulart
Francisco Torggler Filho
Hermes Vieira Barbeiro
Irineu Tadeu Velasco
Luiz Monteiro da Cruz Neto
Heraldo Possolo de Souza
Publication date
01-02-2014
Publisher
Springer US
Published in
Inflammation / Issue 1/2014
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-013-9722-z

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