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Neurological Sciences
Published in: Neurological Sciences 7/2021

01-07-2021 | Neuropathic Pain | Original Article

The increase of neuropathic symptoms in diabetic patients is related with osteopenia

Authors: Elif Börekci, Adem Kara, Mahmut Kılıç, Nermin Tanık, Zeynep T. Ozan, Tekin Yıldırım, Yalçın Aral

Published in: Neurological Sciences | Issue 7/2021

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Abstract

Purpose

To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN).

Methods

In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method.

Results

There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score.

Conclusion

The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia.
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Metadata
Title
The increase of neuropathic symptoms in diabetic patients is related with osteopenia
Authors
Elif Börekci
Adem Kara
Mahmut Kılıç
Nermin Tanık
Zeynep T. Ozan
Tekin Yıldırım
Yalçın Aral
Publication date
01-07-2021
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 7/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04915-3

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