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10-08-2020 | Neurofibromatosis | Case Report

Malignant Peripheral Nerve Sheath Tumour of Uterine Cervix—a Case Report and Review of Literature

Authors: Lekha Madhavan Nair, Rema Prabhakaran Nair, Balaji Radhakrishnan, Francis Vadakkumparambil James

Published in: Indian Journal of Surgical Oncology | Issue 3/2023

Abstract

Malignant peripheral nerve sheath tumour (MPNST) is a rare variety of sarcoma occurring in the uterine cervix. Only 16 cases have been reported in literature till date. There is no clear consensus on the treatment due to the rarity of the disease. This is primarily managed by surgery. Here, we present a case of MPNST of the cervix who was treated with preoperative radiotherapy followed by radical hysterectomy and bilateral salpingo-oophorectomy.

Bansal S, Lewin SN, Burke WM, Deutsch I, Sun X, Herzog TJ, Wright JD (2010) Sarcoma of the cervix: natural history and outcomes. Gynecol Oncol 118(2):134–138. https://doi.org/10.1016/j.ygyno.2010.04.021CrossRefPubMed

Mills AM, Karamchandani JR, Vogel H, Longacre TA (2011) Endocervical fibroblastic malignant peripheral nerve sheath tumor (neurofibrosarcoma): report of a novel entity possibly related to endocervical CD34 fibrocytes. Am J Surg Pathol 35(3):404–412. https://doi.org/10.1097/PAS.0b013e318208f72eCrossRefPubMed

Sloan D (1988) Diagnosis of a tumor with an unusual presentation in the pelvis. Am J Obstet Gynecol 159(4):826–827. https://doi.org/10.1016/S0002-9378(88)80145-5CrossRefPubMed

Junge J, Horn T, Bock J (1989) Primary malignant Schwannoma of the uterine cervix. Case report. Br J Obstet Gynaecol 96(1):111–116CrossRefPubMed

Keel SB, Clement PB, Prat J, Young RH (1998) Malignant schwannoma of the uterine cervix: a study of three cases. Int J Gynecol Pathol 17(3):223–230CrossRefPubMed

Lallas TA, Mehaffey PC, Lager DJ, Van Voorhis BJ, Sorosky JI (1999) Malignant cervical schwannoma: an unusual pelvic tumor. Gynecol Oncol 72(2):238–242. https://doi.org/10.5468/ogs.2019.62.2.134CrossRefPubMed

Bernstein HB, Broman JH, Apicelli A, Kredentser DC (1999) Primary malignant schwannoma of the uterine cervix: a case report and literature review. Gynecol Oncol 74(2):288–292. https://doi.org/10.1006/gyno.1999.5425CrossRefPubMed

Di Giovannantonio L, Bellocci R, Zappacosta R, Zappacosta B, Castrataro A, Liberatore M et al (2005) Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report. Pathologica 97(1):7–9PubMed

Rodriguez AO, Truskinovsky AM, Kasrazadeh M, Leiserowitz GS (2006) Case report: malignant peripheral nerve sheath tumor of the uterine cervix treated with radical vaginal trachelectomy. Gynecol Oncol 100(1):201–204. https://doi.org/10.1016/j.ygyno.2005.08.025CrossRefPubMed

10.

Kim NR, Chung DH, Park CY, Ha SY (2009) Malignant peripheral nerve sheath tumor of the uterine cervix expressing both S-100 protein and HMB-45. J Obstet Gynaecol Res 35(6):1136–1141. https://doi.org/10.1111/j.1447-0756.2009.01078.xCrossRefPubMed

11.

Akhavan A, Moghimi M, Karimi-Zarchi M, Navabii H (2012) Malignant peripheral nerve sheet tumour of cervix. BMJ Case Rep 2012:bcr0220125864. https://doi.org/10.1136/bcr.02.2012.5864CrossRefPubMedPubMedCentral

12.

Dong A, Zuo C, Wang Y, Zhai Z, Xu M (2014) Enhanced CT and FDG PET/CT in primary malignant peripheral nerve sheath tumor of the uterine cervix. Clin Nucl Med 39(9):825–827. https://doi.org/10.1097/RLU.0000000000000299CrossRefPubMed

13.

Sangiorgio V, Zanagnolo V, Aletti G, Bocciolone L, Bruni S, Landoni F et al (2018) Fibroblastic malignant peripheral nerve sheath tumour of the uterine cervix: report of a case and literature review with emphasis on possible differential diagnosis. Int J Gynecol Pathol 37(5):497–503. https://doi.org/10.1097/PGP.0000000000000453CrossRefPubMed

Title: Malignant Peripheral Nerve Sheath Tumour of Uterine Cervix—a Case Report and Review of Literature
Authors: Lekha Madhavan Nair
Rema Prabhakaran Nair
Balaji Radhakrishnan
Francis Vadakkumparambil James
Publication date: 10-08-2020
Publisher: Springer India
Keywords: Neurofibromatosis
Sarcoma
Radiotherapy
Neurofibromatosis
Hysterectomy
Published in: Indian Journal of Surgical Oncology / Issue 3/2023
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-020-01174-8

At a glance: The STEP trials

Springer Medicine

Malignant Peripheral Nerve Sheath Tumour of Uterine Cervix—a Case Report and Review of Literature

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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