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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2007

Open Access 01-06-2007 | Review

Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach

Authors: Nadja Tariverdian, Theoharis C. Theoharides, Friederike Siedentopf, Gabriela Gutiérrez, Udo Jeschke, Gabriel A. Rabinovich, Sandra M. Blois, Petra C. Arck

Published in: Seminars in Immunopathology | Issue 2/2007

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Abstract

Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis.
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Metadata
Title
Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
Authors
Nadja Tariverdian
Theoharis C. Theoharides
Friederike Siedentopf
Gabriela Gutiérrez
Udo Jeschke
Gabriel A. Rabinovich
Sandra M. Blois
Petra C. Arck
Publication date
01-06-2007
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 2/2007
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-007-0077-0

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