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Angiogenesis
Published in: Angiogenesis 1/2008

01-03-2008 | Original Paper

Netrins and UNC5 receptors in angiogenesis

Authors: Catarina Freitas, Bruno Larrivée, Anne Eichmann

Published in: Angiogenesis | Issue 1/2008

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Abstract

Both neuronal and vascular development require guidance to establish a precise branching pattern of these systems in the vertebrate body. Several molecules implicated in axon navigation have also been shown to regulate vessel sprouting. Among these guidance cues, Netrins constitute a family of diffusible molecules with a bifuncional role in axon pathfinding. Recent findings implicate Netrins in other developmental processes, including vascular development. We here review recent studies and discuss the possible dual function of Netrins and its receptors during branching of blood vessels in developmental and pathological angiogenesis.
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Metadata
Title
Netrins and UNC5 receptors in angiogenesis
Authors
Catarina Freitas
Bruno Larrivée
Anne Eichmann
Publication date
01-03-2008
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 1/2008
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-008-9096-2

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