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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2019

Open Access 01-12-2019 | Nerve Injury | Research article

Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease

Authors: Jing Li, Yan Zhang, Hang Zhou, Lei Wang, Zhenchang Wang, Hongyang Li

Published in: BMC Medical Imaging | Issue 1/2019

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Abstract

Background

The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related to other orbital diseases.

Methods

This retrospective study included 225 patients with IgG4-RD admitted at two ophthalmology centers between January 2014 and December 2017. Twenty-six patients had both pre-therapeutic orbital MRI and optic never injury. The causes of optic neuropathy were analyzed, and the special sign in MRI to diagnose IgG4-ROD was also evaluated.

Results

Twelve cases had inflammation of the optic nerve sheath, while 14 cases had compression due to extraocular muscles and pseudo tumor masses. Two cases had hypertrophic cranial pachymeningitis, while one case had hypophysis involving optic chiasma.

Conclusion

The most common causes of optic nerve injury in IgG-4 ROD are inflammation of optic nerve sheath, compression of extraocular muscles, pseudo tumor mass and hypertrophic cranial pachymeningitis, and hypophysis involving optic chiasma.
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Metadata
Title
Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease
Authors
Jing Li
Yan Zhang
Hang Zhou
Lei Wang
Zhenchang Wang
Hongyang Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2019
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-019-0347-z

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