Top

Published in:

01-04-2017 | Head and Neck

Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign

Authors: J. Ben Soussan, R. Deschamps, J. C. Sadik, J. Savatovsky, L. Deschamps, M. Puttermann, M. Zmuda, F. Heran, O. Galatoire, H. Picard, A. Lecler

Published in: European Radiology | Issue 4/2017

Abstract

Objectives

To measure the frequency of infraorbital nerve enlargement (IONE) on magnetic resonance imaging (MRI) in European patients suffering from an IgG4-related ophthalmic disease (IgG4-ROD) as compared to patients suffering from non-IgG4-related ophthalmic disease (non-IgG4-ROD).

Methods

From January 2006 through April 2015, 132 patients were admitted for non-lymphoma, non-thyroid-related orbital inflammation. Thirty-eight had both pre-therapeutic orbital MRI and histopathological IgG4 immunostaining. Fifteen patients were classified as cases of IgG4-ROD and 23 patients as cases of non-IgG4-ROD. Two readers performed blinded analyses of MRI images. The main criterion was the presence of an IONE, defined as the infraorbital nerve diameter being greater than the optic nerve diameter in the coronal section.

Results

IONE was present in 53% (8/15) of IgG4-ROD cases whereas it was never present (0/23) in cases of non-IgG4-ROD (P < 0.0001). IONE was only present in cases where, on MRI, the inflammation of the inferior quadrant was present and in direct contact with the ION canal.

Conclusions

In European patients suffering from orbital inflammation, the presence of IONE on an MRI is a specific sign of IgG4-ROD. Recognition of this pattern may facilitate the accurate diagnosis for clinicians and allow for the adequate management and appropriate care of their patients.

Key points

• IONE on an MRI is a specific sign of IgG4-ROD.

• IONE recognition allows for a quicker diagnosis and appropriate management.

• IONE appears when inflammation is in direct contact with the ION canal.

Hamano H, Kawa S, Horiuchi A et al (2001) High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344:732–738CrossRefPubMed

Umehara H, Okazaki K, Masaki Y et al (2012) A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol Jpn Rheum Assoc 22:1–14CrossRef

Yamamoto M, Ohara M, Suzuki C et al (2004) Elevated IgG4 concentrations in serum of patients with Mikulicz’s disease. Scand J Rheumatol 33:432–433CrossRefPubMed

Kitagawa S, Zen Y, Harada K et al (2005) Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner’s tumor). Am J Surg Pathol 29:783–791CrossRefPubMed

Stone JH, Zen Y, Deshpande V (2012) IgG4-related disease. N Engl J Med 366:539–551CrossRefPubMed

Katsura M, Mori H, Kunimatsu A et al (2012) Radiological features of IgG4-related disease in the head, neck, and brain. Neuroradiology 54:873–882CrossRefPubMed

Umehara H, Okazaki K, Masaki Y et al (2012) Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol Jpn Rheum Assoc 22:21–30CrossRef

Wu A, Andrew NH, McNab AA, Selva D (2015) IgG4-related ophthalmic disease: pooling of published cases and literature review. Curr Allergy Asthma Rep 15:27CrossRefPubMed

Wallace ZS, Deshpande V, Stone JH (2014) Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review. Semin Arthritis Rheum 43:806–817CrossRefPubMed

10.

McNab AA, McKelvie P (2015) IgG4-related ophthalmic disease. Part I: background and pathology. Ophthal Plast Reconstr Surg 31:83–88CrossRefPubMed

11.

Mulholland GB, Jeffery CC, Satija P, Côté DWJ (2015) Immunoglobulin G4-related diseases in the head and neck: a systematic review. J Otolaryngol Head Neck Surg. doi:10.1186/s40463-015-0071-9

12.

Deschamps R, Deschamps L, Depaz R et al (2013) High prevalence of IgG4-related lymphoplasmacytic infiltrative disorder in 25 patients with orbital inflammation: a retrospective case series. Br J Ophthalmol 97:999–1004CrossRefPubMed

13.

Lindfield D, Attfield K, McElvanney A (2012) Systemic immunoglobulin G4 (IgG4) disease and idiopathic orbital inflammation; removing “idiopathic” from the nomenclature? Eye 26:623–629CrossRefPubMedPubMedCentral

14.

Andrew NH, Sladden N, Kearney DJ, Selva D (2015) An analysis of IgG4-related disease (IgG4-RD) among idiopathic orbital inflammations and benign lymphoid hyperplasias using two consensus-based diagnostic criteria for IgG4-RD. Br J Ophthalmol 99:376–381CrossRefPubMed

15.

Wallace ZS, Khosroshahi A, Jakobiec FA et al (2012) IgG4-related systemic disease as a cause of “idiopathic” orbital inflammation, including orbital myositis, and trigeminal nerve involvement. Surv Ophthalmol 57:26–33CrossRefPubMed

16.

Katsura M, Morita A, Horiuchi H et al (2011) IgG4-related inflammatory pseudotumor of the trigeminal nerve: another component of IgG4-related sclerosing disease? AJNR Am J Neuroradiol 32:E150–E152CrossRefPubMed

17.

Hardy TG, McNab AA, Rose GE (2014) Enlargement of the Infraorbital Nerve. Ophthalmology 121:1297–1303CrossRefPubMed

18.

Sogabe Y, Ohshima K, Azumi A et al (2014) Location and frequency of lesions in patients with IgG4-related ophthalmic diseases. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Für Klin Exp Ophthalmol 252:531–538CrossRef

19.

Takano K, Yajima R, Seki N et al (2014) A study of infraorbital nerve swelling associated with immunoglobulin G4 Mikulicz’s disease. Mod Rheumatol Jpn Rheum Assoc 24:798–801CrossRef

20.

Ohshima K-I, Sogabe Y, Sato Y (2012) The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease. Jpn J Ophthalmol 56:380–382CrossRefPubMed

21.

Tiegs-Heiden CA, Eckel LJ, Hunt CH et al (2014) Immunoglobulin G4-related disease of the orbit: imaging features in 27 patients. AJNR Am J Neuroradiol 35:1393–1397CrossRefPubMed

22.

Goto H, Takahira M, Takahira M et al (2015) Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol 59:1–7CrossRefPubMed

23.

R Core Team (2014) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/

24.

Landis JR, Koch GG (1977) An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 33:363–374CrossRefPubMed

25.

Inoue D, Zen Y, Sato Y et al (2012) IgG4-Related perineural disease. Int J Rheumatol 2012:1–9CrossRef

26.

Deshpande V, Zen Y, Chan JK et al (2012) Consensus statement on the pathology of IgG4-related disease. Mod Pathol 25:1181–1192CrossRefPubMed

27.

Khosroshahi A, Wallace ZS, Crowe JL et al (2015) International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease. Arthritis Rheumatol Hoboken NJ 67:1688–1699CrossRef

28.

Plaza JA, Garrity JA, Dogan A et al (2011) Orbital inflammation with IgG4-positive plasma cells: manifestation of IgG4 systemic disease. Arch Ophthalmol Chic Ill 129:421–428, 1960CrossRef

29.

Sato Y, Ohshima K, Ichimura K et al (2008) Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int 58:465–470CrossRefPubMed

30.

Matsuo T, Ichimura K, Sato Y et al (2010) Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. J Clin Exp Hematop JCEH 50:129–142CrossRefPubMed

31.

Soussan M, Medjoul A, Badelon I et al (2014) IgG4-related diffuse perineural disease. Neurology 83:1877–1878CrossRefPubMed

32.

Chong VF, Fan YF (1997) Pterygopalatine fossa and maxillary nerve infiltration in nasopharyngeal carcinoma. Head Neck 19:121–125CrossRefPubMed

33.

Nager GT (1984) Neurinomas of the trigeminal nerve. Am J Otolaryngol 5:301–333CrossRefPubMed

34.

Hiwatashi A, Yoshiura T, Togao O et al (2014) Diffusivity of intraorbital lymphoma vs. IgG4-related DISEASE: 3D turbo field echo with diffusion-sensitised driven-equilibrium preparation technique. Eur Radiol 24:581–586CrossRefPubMed

35.

Shah R, Roberson GH, Curé JK (2009) Correlation of MR imaging findings and clinical manifestations in neurosarcoidosis. AJNR Am J Neuroradiol 30:953–961CrossRefPubMed

36.

Yu W-K, Kao S-C, Yang C-F et al (2015) Ocular adnexal IgG4-related disease: clinical features, outcome, and factors associated with response to systemic steroids. Jpn J Ophthalmol 59:8–13CrossRefPubMed

37.

Carruthers MN, Topazian MD, Khosroshahi A et al (2015) Rituximab for IgG4-related disease: a prospective, open-label trial. Ann Rheum Dis 74:1171–1177CrossRefPubMed

Title: Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign
Authors: J. Ben Soussan
R. Deschamps
J. C. Sadik
J. Savatovsky
L. Deschamps
M. Puttermann
M. Zmuda
F. Heran
O. Galatoire
H. Picard
A. Lecler
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4481-5

At a glance: The STEP trials

Springer Medicine

Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign

Abstract

Objectives

Methods

Results

Conclusions

Key points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

Please log in to get access to this content

Other articles of this Issue 4/2017

Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

Should fat in the radiofrequency ablation zone of hepatocellular adenomas raise suspicion for residual tumour?

Diagnostic performance of MR imaging findings and quantitative values in the differentiation of seromucinous borderline tumour from endometriosis-related malignant ovarian tumour

Prospective 1-year follow-up pilot study of CT-guided microwave ablation in the treatment of bone and soft-tissue malignant tumours

MR-guided percutaneous biopsy of solitary pulmonary lesions using a 1.0-T open high-field MRI scanner with respiratory gating

Prediction of presence of kidney disease in patients undergoing intravenous iodinated contrast enhanced computed tomography: a validation study