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Published in: Pediatric Cardiology 4/2004

01-07-2004

Nerve Growth Factor Plasma Levels and Ventricular Repolarization in Rett Syndrome

Authors: F. Guideri, M. Acampa, G. Calamandrei, L. Aloe, M. Zappella, Y. Hayek

Published in: Pediatric Cardiology | Issue 4/2004

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Abstract

Rett syndrome is a severe neurological developmental disorder. In this syndrome, the high incidence of sudden death is correlated with an alteration of ventricular repolarization. The purpose of this study was to evaluate plasmatic levels of nerve growth factor (NGF) in Rett patients with prolonged corrected QT (QTc) interval in comparison with those of Rett patients with normal QTc. We observed 23 female Rett patients (9.9 ± 4.7 years). NGF plasma levels and QTc interval were measured in all patients. Student t-test was performed for statistical analysis. NGF plasma levels were significantly lower in Rett patients with QTc interval prolongation (QTc > 0.44 sec) in comparison with Rett patients with a normal QTc interval (4.5 ± 4.5 vs 11 ± 8.3 pg/ml, p = 0.02). The alteration of NGF levels, observed in Rett patients with a long QTc interval, may explain the presence of an altered ventricular repolarization associated with a higher risk of cardiac arrhythmias.
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Metadata
Title
Nerve Growth Factor Plasma Levels and Ventricular Repolarization in Rett Syndrome
Authors
F. Guideri
M. Acampa
G. Calamandrei
L. Aloe
M. Zappella
Y. Hayek
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Pediatric Cardiology / Issue 4/2004
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-002-0406-y

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