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02-03-2023 | Nephrectomy | Original Article

Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy

Authors: Alexander Yu. Volkov, Sergey N. Nered, Nikolay A. Kozlov, Ivan S. Stilidi, Peter P. Arhiri, Elena Yu. Antonova

Published in: Indian Journal of Surgical Oncology | Special Issue 1/2024

Abstract

This study was aimed at determining the indications for combined and organ-preserving operations. The study included 190 patients with retroperitoneal liposarcoma (RLPS). The influence of the following factors on the overall survival (OS) and recurrence-free survival (RFS) were studied: involvement of adjacent organs in the tumor, volume of surgical intervention. OS and RFS were worse in pathologically confirmed visceral invasion in the both RLPS low grade and high grade (p = 0.000). In RLPS low grade, there was no significant difference in OS and RFS between the group of patients who underwent combined surgery without confirmed visceral invasion and the group of patients who underwent organ–preserving surgery (p > 0.080). In RLPS high grade, OS and RFS were higher in the group of patients who underwent combined surgery without confirmed visceral invasion than in the group of patients who underwent organ–preserving surgery (p < 0.050). In RLPS low grade, it is advisable to perform organ-preserving operations, including nephrosaving operations. In RLPS high grade, the organ-preserving operations worsen long-term results and prognosis. Combined operations including nephrectomy are justified in RLPS high grade.

Liles JS, Tzeng CW, Short JJ, Kulesza P, Heslin MJ (2009) Retroperitoneal and intra-abdominal sarcoma. Curr Probl Surg 46(6):445–503. https://doi.org/10.1067/j.cpsurg.2009.01.004CrossRefPubMed

Dalal KM, Kattan MW, Antonescu CR, Brennan M, Singer S (2006) Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, ortrunk. Ann Surg 244(3):381–391. https://doi.org/10.1097/01.sla.0000234795.98607.00CrossRefPubMedPubMedCentral

Fletcher CD, Bridge JA, Hogendoorn P, Mertens F (2013) WHO Classification of Tumours of soft tissue and bone. 4th Ed. IARC 33–44

Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF (2008) Why do patients with low-grade soft tissue sarcoma die? Ann Surg Oncol 15(12):3550–3560. https://doi.org/10.1245/s10434-008-0163-0CrossRefPubMedPubMedCentral

Matthyssens LE, Creytens D, Ceelen WP (2015) Retroperitoneal liposarcoma: current insights in diagnosis and treatment. Front Surg 10(2):4. https://doi.org/10.3389/fsurg.2015.00004.PMID:25713799;PMCID:PMC4322543CrossRef

Raut CP, Miceli R, Strauss DC et al (2016) External validation of a multi-institutional retroperitoneal sarcoma nomogram. Cancer 122(9):1417–1424. https://doi.org/10.1002/cncr.29931CrossRefPubMed

Nered SN, Stilidi IS, Klimenkov AA, Bolotsky VI, Anurova OA (2012) Clinico-morphological properties and surgical treatment results in retroperitoneal liposarcomas. Problems Oncol 58(1):94–100 (in Russian)

Bonvalot S, Rivoire M, Castaing M, Stoeckle E, Le Cesne A, Blay JY, Laplanche A (2009) Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J Clin Oncol 27(1):31–37. https://doi.org/10.1200/JCO.2008.18.0802CrossRefPubMed

Strauss DC, Hayes AJ, Thway K, Moskovic EC, Fisher C, Thomas JM (2010) Surgical management of primary retroperitoneal sarcoma. Br J Surg 97(5):698–706. https://doi.org/10.1002/bjs.6994CrossRefPubMed

10.

Volkov AYu, Nered SN, Lyubchenko LN (2019) Retroperitoneal non-organ liposarcomas: the modern concept. Sib J Oncol 18(5): 86–96. https://doi.org/10.21294/1814-4861-2019-18-5-86-96

11.

Raut CP, Callegaro D, Miceli R et al (2019) Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG. Clin Cancer Res 25(8):2664–2671. https://doi.org/10.1158/1078-0432.CCR-18-2700CrossRefPubMed

12.

Gronchi A, Lo Vullo S, Fiore M et al (2009) Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients. J Clin Oncol 27(1):24–30. https://doi.org/10.1200/JCO.2008.17.8871CrossRefPubMed

13.

Bonvalot S, Miceli R, Berselli M et al (2010) Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control. Ann Surg Oncol 17(6):1507–1514. https://doi.org/10.1245/s10434-010-1057-5CrossRefPubMed

14.

Kaprin AD, Riabov AB, Chomiakov VM et al. Surgical treatment of retroperitoneal tumors involving vena cava inferior. Bone and soft tissue sarcomas, tumors of the skin. 2016;(3):48-59

15.

Afanasyev SG, Dobrodeev AYu, Volkov MYu (2015) Surgical treatment outcomes of non-organic retroperitoneal tumors. Sib J Oncol 1(3):51–54

16.

Pisters PW (2009) Resection of some – but not all – clinically uninvolved adjacent viscera as part of surgery for retroperitoneal soft tissue sarcomas. J Clin Oncol 27(1):6–8. https://doi.org/10.1200/JCO.2008.18.7138CrossRefPubMed

17.

Raut CP, Swallow CJ (2010) Are radical compartmental resections for retroperitoneal sarcomas justified? Ann Surg Oncol 17(6):1481–1484. https://doi.org/10.1245/s10434-010-1061-9CrossRefPubMed

18.

Gronchi A, Miceli R, Colombo C et al (2012) Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas. Ann Oncol 23(4):1067–1073. https://doi.org/10.1093/annonc/mdr323CrossRefPubMed

19.

Singer S, Antonescu CR, Riedel E, Brennan MF (2003) Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 238(3):358–70; discussion 370–1. https://doi.org/10.1097/01.sla.0000086542.11899.38

20.

Lahat G, Anaya DA, Wang X, Tuvin D, Lev D, Pollock RE. Resectable well-differentiated versus dedifferentiated liposarcomas: two different diseases possibly requiring different treatment approaches. Ann Surg 14501502

21.

Anaya DA, Lahat G, Wang X et al (2009) Establishing prognosis in retroperitoneal sarcoma: a new histology-based paradigm. Ann Surg Oncol 16(3):667–675. https://doi.org/10.1245/s10434-008-0250-2CrossRefPubMed

22.

Anaya DA, Lahat G, Liu J et al (2009) Multifocality in retroperitoneal sarcoma: a prognostic factor critical to surgical decision-making. Ann Surg 249(1):137–142. https://doi.org/10.1097/SLA.0b013e3181928f2fCrossRefPubMed

23.

Tseng W, Martinez SR, Tamurian RM, Borys D, Canter RJ (2012) Histologic type predicts survival in patients with retroperitoneal soft tissue sarcoma. J Surg Res 172(1):123–130. https://doi.org/10.1016/j.jss.2010.07.056CrossRefPubMed

24.

Tseng WW, Madewell JE, Wei W et al (2014) Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann Surg Oncol 21(7):2136–2143. https://doi.org/10.1245/s10434-014-3643-4CrossRefPubMed

25.

Gronchi A, Pollock RE (2013) Quality of local treatment or biology of the tumor: which are the trump cards for loco-regional control of retroperitoneal sarcoma? Ann Surg Oncol 20(7):2111–2113. https://doi.org/10.1245/s10434-013-2971-0CrossRefPubMed

26.

Stilidi IS, Nikulin MP, Nered SN, Davydov MM, Bolotskiĭ VI, Gubina GI (2013) Combined operations by retroperitoneal liposarcoma]. Khirurgiia (Mosk) (6):20–5. Russian

27.

Rasulov RR, Muratov AA, Dvornichenko VV, Morikov DD, Teterina TP (2017) Renal replantation at extended and combined resection of retroperitoneal liposarcoma (Case report). Acta Biomed Sci 1:130–135

28.

Brierley JD, Gospodarowicz MK, Wittekind Ch (2017) TNM classification of malignant tumours, 8th edn. Wiley-Blackwell, New York, p 272

29.

Setsu N, Miyake M, Wakai S et al (2016) Primary Retroperitoneal Myxoid Liposarcomas. Am J Surg Pathol 40(9):1286–1290. https://doi.org/10.1097/PAS.0000000000000657CrossRefPubMedPubMedCentral

30.

Volkov AYu, Safronova VM, Nered SN, Lyubchenko LN, Stilidi IS (2020) Genetic polymorphism of retroperitoneal myxoid liposarcoma. Sib J Oncol 19(3):89–96. (In Russ.) https://doi.org/10.21294/1814-4861-2020-19-3-89-96

31.

Nered SN, Volkov A.Yu, Kozlov NA, et al. (2020) Prognostic relevance of the TNM classification 8th edition and new criteria of staging for retroperitoneal liposarcoma. J Modern Oncol (In Russ.) 22 (3): 120–126. https://doi.org/10.26442/18151434.2020.3.200220

Title: Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy
Authors: Alexander Yu. Volkov
Sergey N. Nered
Nikolay A. Kozlov
Ivan S. Stilidi
Peter P. Arhiri
Elena Yu. Antonova
Publication date: 02-03-2023
Publisher: Springer India
Keywords: Nephrectomy
Liposarcoma
Nephrectomy
Sarcoma
Nephrectomy
Published in: Indian Journal of Surgical Oncology / Issue Special Issue 1/2024
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-023-01726-8

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Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy

Abstract

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