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01-03-2009 | Bone and Soft Tissue Sarcomas

Establishing Prognosis in Retroperitoneal Sarcoma: A New Histology-Based Paradigm

Authors: Daniel A. Anaya, MD, Guy Lahat, MD, Xuemei Wang, MS, Lianchun Xiao, MS, Daniel Tuvin, MD, Peter W. Pisters, MD, Dina C. Lev, MD, Raphael E. Pollock, MD, PhD

Published in: Annals of Surgical Oncology | Issue 3/2009

Abstract

Background

Retroperitoneal sarcoma (RPS) American Joint Committee on Cancer (AJCC) staging applies to primary tumors only; due to specific RPS disease characteristics, staging is driven primarily by grade, stratifying patients into only two distinct prognostic subsets. The objective of this study was to help improve currently available staging for RPS by establishing a new, more robust histology-based prognostic system.

Methods

A RPS database of 1,118 patients seen at our institution (1996–2006) identified 343 patients treated for resectable primary or recurrent disease; a histologic subtype-based RPS prognostic system was designed and evaluated for prognostic accuracy in comparison with the current AJCC staging system.

Results

Histology stratified patients into three groups by prognosis (P < 0.0002): atypical lipomatous tumor (ALT), non-ALT liposarcoma (LPS), and “other,” an improvement compared with AJCC staging which could only identify two distinct prognostic groups. In contrast to AJCC staging, this prognostic stratification was reproducible for both primary and recurrent RPS (P < 0.0001). After multivariate analysis, LPS (P = 0.0004) and “other” histologies (P < 0.0001) were found to be independent predictors of worse survival. The concordance ratio of this model was 0.74, equivalent to that of the model using the AJCC staging system.

Conclusions

A histology-based RPS prognostic system has two advantages over AJCC staging: it can stratify into three versus two distinct prognostic groups, and it can be used for both primary and recurrent RPS. Distinct risk stratification is critical for specific assessment of prognosis as well as decisions regarding individualized adjuvant therapies, hence the advantage of a three-tiered histology-based system applicable in both primary and recurrent RPS.

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Title: Establishing Prognosis in Retroperitoneal Sarcoma: A New Histology-Based Paradigm
Authors: Daniel A. Anaya, MD
Guy Lahat, MD
Xuemei Wang, MS
Lianchun Xiao, MS
Daniel Tuvin, MD
Peter W. Pisters, MD
Dina C. Lev, MD
Raphael E. Pollock, MD, PhD
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2009
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-008-0250-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Establishing Prognosis in Retroperitoneal Sarcoma: A New Histology-Based Paradigm

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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