Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Urology
Published in: BMC Urology 1/2021

Open Access 01-12-2021 | Nephrectomy | Research

Study on the correlation between preoperative inflammatory indexes and adhesional perinephric fat before laparoscopic partial nephrectomy

Authors: Teng Ma, Lin Cong, Qianli Ma, Zhaoqin Huang, Qianqian Hua, Xiaojiao Li, Ximing Wang, Yunchao Chen

Published in: BMC Urology | Issue 1/2021

Login to get access

Abstract

Objective

This study was aimed to evaluate the effect of preoperative composite inflammatory index on adhesional perinephric fat (APF), providing a help for preoperative risk assessment of laparoscopic partial nephrectomy (LPN) in patients with renal cell carcinoma.

Materials and methods

A retrospective study was conducted on 231 patients with renal cell carcinoma, who underwent laparoscopic partial nephrectomy. They were divided into two groups according to whether there was APF during operation. Relevant clinical data, laboratory parameters and imaging examination were obtained before operation to calculate the composite inflammatory index and MAP score. The composite inflammatory index was divided into high value group and low value group by ROC curve method. The related predictive factors of APF were analyzed by logistic regression method.

Results

The APF was found in 105 patients (45.5%). In multivariate analysis, systemic immune inflammation index (SII) (high/low), MAP score, tumor size and perirenal fat thickness were independent predictors of APF. The operation time of patients with APF was longer, and the difference of blood loss was not statistically significant.

Conclusion

SII is an independent predictor of APF before laparoscopic partial nephrectomy.
Trial registration ChiCTR, ChiCTR2100045944. Registered 30 April 2021—Retrospectively registered, http://​www.​chictr.​org.​cn/​showproj.​aspx?​proj=​125703.
Literature
1.
Campbell S, Uzzo RG, Allaf ME, Bass EB, Cadeddu JA, Chang A, Clark PE, Davis BJ, Derweesh IH, Giambarresi L, et al. Renal mass and localized renal cancer: AUA guideline. J Urol. 2017;198(3):520–9.CrossRef
2.
Kawamura N, Saito K, Inoue M, Ito M, Kijima T, Yoshida S, Yokoyama M, Ishioka J, Matsuoka Y, Kihara K, et al. Adherent Perinephric Fat in Asian patients: Predictors and impact on perioperative outcomes of partial nephrectomy. Urol Int. 2018;101(4):437–42.CrossRef
3.
Martin L, Rouviere O, Bezza R, Bailleux J, Abbas F, Schott-Pethelaz AM, Ruffion A, Paparel P. Mayo adhesive probability score is an independent computed tomography scan predictor of adherent Perinephric fat in open partial nephrectomy. Urology. 2017;103:124–8.CrossRef
4.
Bylund JR, Qiong H, Crispen PL, Venkatesh R, Strup SE. Association of clinical and radiographic features with perinephric “sticky” fat. J Endourol. 2013;27(3):370–3.CrossRef
5.
Kocher NJ, Kunchala S, Reynolds C, Lehman E, Nie S, Raman JD. Adherent perinephric fat at minimally invasive partial nephrectomy is associated with adverse peri-operative outcomes and malignant renal histology. BJU Int. 2016;117(4):636–41.CrossRef
6.
Davidiuk AJ, Parker AS, Thomas CS, Leibovich BC, Castle EP, Heckman MG, Custer K, Thiel DD. Mayo adhesive probability score: an accurate image-based scoring system to predict adherent perinephric fat in partial nephrectomy. Eur Urol. 2014;66(6):1165–71.CrossRef
7.
Khene ZE, Peyronnet B, Mathieu R, Fardoun T, Verhoest G, Bensalah K. Analysis of the impact of adherent perirenal fat on peri-operative outcomes of robotic partial nephrectomy. World J Urol. 2015;33(11):1801–6.CrossRef
8.
Aoyama T, Takano M, Miyamoto M, Yoshikawa T, Kato K, Sakamoto T, Takasaki K, Matsuura H, Soyama H, Hirata J, et al. Pretreatment neutrophil-to-lymphocyte ratio was a predictor of lymph node metastasis in endometrial cancer patients. Oncology. 2019;96(5):259–67.CrossRef
9.
Lee SH, Chung MJ, Kim B, Lee HS, Lee HJ, Heo JY, Kim YJ, Park JY, Bang S, Park SW, et al. The significance of the prognostic nutritional index for all stages of pancreatic cancer. Nutr Cancer. 2017;69(3):512–9.CrossRef
10.
Wang L, Wang C, Wang J, Huang X, Cheng Y. A novel systemic immune-inflammation index predicts survival and quality of life of patients after curative resection for esophageal squamous cell carcinoma. J Cancer Res Clin Oncol. 2017;143(10):2077–86.CrossRef
11.
Yang B, Ma LL, Qiu M, Xia HZ, He W, Meng TY, Lu M, Lu J. A novel nephrometry scoring system for predicting peri-operative outcomes of retroperitoneal laparoscopic partial nephrectomy. Chin Med J (Engl). 2020;133(5):577–82.CrossRef
12.
Abou Youssif T, Tanguay S. Natural history and management of small renal masses. Current Oncology. 2009;16:2–7.CrossRef
13.
Yao Y, Gong H, Pang Y, Gu L, Niu S, Xu Y, Li P, Liu K, Tang L, Xuan Y, et al. Risk factors influencing the thickness and stranding of perinephric fat of mayo adhesive probability score in minimally invasive nephrectomy. Med Sci Monit. 2019;25:3825–31.CrossRef
14.
Minervini A, Mari A, Borghesi M, Antonelli A, Bertolo R, Bianchi G, Brunocilla E, Ficarra V, Fiori C, Longo N, et al. The occurrence of intraoperative complications during partial nephrectomy and their impact on postoperative outcome: results from the RECORd1 project. Minerva Urol Nefrol. 2019;71(1):47–54.CrossRef
15.
Fabrizio DIM, Vittori G, Campi R, Mari A, Tellini R, Sforza S, Sessa F, Lucarini S, Miele V, Vignozzi L, et al. Clinical predictors and significance of adherent perinephric fat assessed with Mayo Adhesive Probability (MAP) score and perinephric fat surface density (PnFSD) at the time of partial nephrectomy for localized renal mass. A single high-volume referral center experience. Minerva Urol Nephrol. 2021;73(2):225–32.
16.
Gorin MA, Mullins JK, Pierorazio PM, Jayram G, Allaf ME. Increased intra-abdominal fat predicts perioperative complications following minimally invasive partial nephrectomy. Urology. 2013;81(6):1225–30.CrossRef
17.
Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? The Lancet. 2001;357(9255):539–45.CrossRef
18.
Asahi Y, Kubonishi I, Imamura J, Kamioka M. Matsushita H: Establishment of a clonal cell line producing granulocyte colony-stimulating factor and parathyroid hormone-related protein from a lung cancer patient with leukocytosis and hypercalcemia. Jpn J Cancer Res. 1996;87(5):451–8.CrossRef
19.
Zhang J, Huang SH, Li H, Li Y, Chen XL, Zhang WQ, Chen HG, Gu LJ. Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer. Med Oncol. 2013;30(1):352.CrossRef
20.
Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41(1):49–61.CrossRef
21.
Wada N, Zaki MA, Hori Y, Hashimoto K, Tsukaguchi M, Tatsumi Y, Ishikawa J, Tominaga N, Sakoda H, Take H, et al. Tumour-associated macrophages in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group. Histopathology. 2012;60(2):313–9.CrossRef
22.
Nieswandt B, Hafner M, Echtenacher B, Mannel DN. Mannel DN: Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 1999;59(6):1295–300.PubMed
23.
Alexandrakis MG, Passam FH, Perisinakis K, Ganotakis E, Margantinis G, Kyriakou DS, Bouros D. Serum proinflammatory cytokines and its relationship to clinical parameters in lung cancer patients with reactive thrombocytosis. Respir Med. 2002;96(8):553–8.CrossRef
24.
Liu J-S, Huang Y, Yang X. Feng J-F: A nomogram to predict prognostic values of various inflammatory biomarkers in patients with esophageal squamous cell carcinoma. Am J Cancer Res. 2015;15(5):2180–9.
25.
Krenn-Pilko S, Langsenlehner U, Thurner EM, Stojakovic T, Pichler M, Gerger A, Kapp KS, Langsenlehner T. The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer. 2014;110(10):2524–30.CrossRef
26.
Azab B, Mohammad F, Shah N, Vonfrolio S, Lu W, Kedia S, Bloom SW. The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer. Cancer Biomark. 2014;14(5):303–12.CrossRef
27.
Feng JF, Chen S, Yang X. Systemic immune-inflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus. Medicine (Baltimore). 2017;96(4):e5886.CrossRef
28.
Jomrich G, Paireder M, Kristo I, Baierl A, Ilhan-Mutlu A, Preusser M, Asari R, Schoppmann SF. High systemic immune-inflammation index is an adverse prognostic factor for patients with gastroesophageal adenocarcinoma. Ann Surg. 2019;273(3):532–41.CrossRef
29.
Narita S, Kumazawa T, Tsuchiya N, Mingguo H, Saito M, Inoue T, Tsuruta H, Numakura K, Maeno A, Nanjo H, Satoh S. Host-related risk factors for adherent perinephric fat in healthy individuals undergoing laparoscopic living-donor nephrectomy. Surg Laparosc Endosc Percutan Tech. 2017;27(4):e69–73.CrossRef
30.
Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92(3):347–55.CrossRef
31.
Kosaka H, Yoshimoto T, Yoshimoto T, Fujimoto J, Nakanishi K. Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation. Nat Med. 2008;14(4):437–41.CrossRef
32.
Dariane C, Le Guilchet T, Hurel S, Audenet F, Beaugerie A, Badoual C, Tordjman J, Clement K, Urien S, Pietak M, et al. Prospective assessment and histological analysis of adherent perinephric fat in partial nephrectomies. Urol Oncol. 2017;35(2):e39.CrossRef
33.
Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A. Cancer and inflammation: Promise for biologic therapy. J Immunother. 2010;33(4):335–51.CrossRef
34.
Kapur R, Semple JW. Platelets as immune-sensing cells. Blood Adv. 2016;22(1):10–4.CrossRef
35.
Druce MR, Bharwani N, Akker SA, Drake WM, Rockall A, Grossman AB. Intra-abdominal fibrosis in a recent cohort of patients with neuroendocrine ('carcinoid’) tumours of the small bowel. QJM. 2010;103(3):177–85.CrossRef
36.
Macleod LC, Hsi RS, Gore JL, Wright JL, Harper JD. Perinephric fat thickness is an independent predictor of operative complexity during robot-assisted partial nephrectomy. J Endourol. 2014;28(5):587–91.CrossRef
37.
Mari A, Campi R, Schiavina R, Amparore D, Antonelli A, Artibani W, Barale M, Bertini R, Borghesi M, Bove P, et al. Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project). BJU Int. 2019;124(1):93–102.CrossRef
Metadata
Title
Study on the correlation between preoperative inflammatory indexes and adhesional perinephric fat before laparoscopic partial nephrectomy
Authors
Teng Ma
Lin Cong
Qianli Ma
Zhaoqin Huang
Qianqian Hua
Xiaojiao Li
Ximing Wang
Yunchao Chen
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-021-00940-2

Other articles of this Issue 1/2021

BMC Urology 1/2021 Go to the issue

Research

Clinical significance and risk factors of urethrovesical anastomotic urinary leakage following robot-assisted radical prostatectomy: a multi-institutional study

Research article

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

Research

Diagnosis and treatment of anterior urethral strictures in China: an internet-based survey

Research

Comparative study of renal drainage with different ureteral stents subject to extrinsic ureteral obstruction using an in vitro ureter-stent model

Research

Preoperative aspartate transaminase/alanine transaminase ratio as a prognostic biomarker in primary non-muscle-invasive bladder cancer: a propensity score-matched study

Research article

Role of microRNA-381 in bladder cancer growth and metastasis with the involvement of BMI1 and the Rho/ROCK axis