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BMC Urology

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Open Access 01-12-2021 | Research

Comparative study of renal drainage with different ureteral stents subject to extrinsic ureteral obstruction using an in vitro ureter-stent model

Authors: Yaniv Shilo, Jonathan Modai, Dan Leibovici, Ishai Dror, Brian Berkowitz

Published in: BMC Urology | Issue 1/2021

Abstract

Background

To compare the efficacy of different ureteral stents subject to extrinsic ureteral obstruction (EUO), in a controlled in vitro stented ureter experiment.

Methods

We employ an in vitro ureter-stent experimental set-up, with latex tubing simulating flexible ureters attached to vessels simulating renal units and bladders. The flow behavior of five ureteral stents—polymeric 8F, tandem 6F, tandem 7F, endopyelotomy and metal—was tested under a ureteral deformation configuration of 40°, with 2000 g external force over a 3.5 cm length of the ureter. A constant fluid flow was applied through the ureter-stent configurations, and pressure fluctuations in the renal unit were monitored. We considered a renal unit pressure of 10 cmH₂O or flow discontinuation in the bladder as stent failure. Urine containing debris was mimicked by use of a colloidal solution.

Results

Of all assessed ureteral stents, under EUO conditions, only the single 8F stents remained patent throughout the length of the experiment. All other stents—tandem 6F and 7F, single 7F, metal and endopyelotomy—displayed limitations.

Conclusions

Tandem and metal stents show no superiority over large luminal polymeric stents for EUO treatment in this in vitro model. Larger luminal stents offer excellent resistance to external pressure and allow adequate colloidal flow. The need for frequent exchange and bladder irritation should also be considered in the choice of stent configuration for treatment of kidney drainage under EUO.

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Title: Comparative study of renal drainage with different ureteral stents subject to extrinsic ureteral obstruction using an in vitro ureter-stent model
Authors: Yaniv Shilo
Jonathan Modai
Dan Leibovici
Ishai Dror
Brian Berkowitz
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-021-00865-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparative study of renal drainage with different ureteral stents subject to extrinsic ureteral obstruction using an in vitro ureter-stent model

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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