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Archives of Gynecology and Obstetrics

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01-03-2019 | Neonatal Hypoglycemia | Gynecologic Endocrinology and Reproductive Medicine

Health care and risk of adverse pregnancy outcomes among diabetic women: an updated meta-analysis

Authors: Guo-Hong Xie, Zan Zheng, Tao-Cheng Liu, Lu-Lu Qing, Xiu-Qin Hong, Wen-Ting Zha, Yuan Lv

Published in: Archives of Gynecology and Obstetrics | Issue 3/2019

Abstract

Purpose

Diabetic women appear to have adverse pregnancy outcomes. Although there were two meta-analyzes that examined the association between health care and adverse pregnancy outcomes, their results were limited because they only included congenital anomaly and perinatal mortality, and they did not clarify the detailed situations of diabetes and health care. This meta-analysis aims to completely evaluate the effects of health care in improving adverse pregnancy outcomes among diabetic mothers.

Methods

CNKI, EMBASE, Web of Science, and PubMed databases were searched for eligible studies up to December 2017, without any restrictions. Relevant cohort studies characterizing the relationship between health care and adverse pregnancy outcomes were selected for inclusion in the meta-analysis. We also screened the reference list of relevant studies. The fixed-effect models or random-effect models were used to calculate the risk estimates. The potential sources of heterogeneity were explored by stratified and sensitivity analyzes.

Results

Twenty-one studies with 6685 cases were included in our analysis. Health care was associated with significantly decreased risk of congenital anomaly (RR 0.237; 95% CI 0.166–0.338), perinatal death (RR 0.457; 95% CI 0.294–0.712), large for gestational age (LGA) (RR 0.794; 95% CI 0.640–0.986), and neonatal hypoglycemia (RR 0.672; 95% CI 0.486–0.929). Publication bias was not found in most results, with the exception of congenital anomaly and small for gestational age (SGA).

Conclusion

Health care is associated with decreased risk of congenital anomaly, perinatal death, LGA, neonatal hypoglycemia.

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Title: Health care and risk of adverse pregnancy outcomes among diabetic women: an updated meta-analysis
Authors: Guo-Hong Xie
Zan Zheng
Tao-Cheng Liu
Lu-Lu Qing
Xiu-Qin Hong
Wen-Ting Zha
Yuan Lv
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Neonatal Hypoglycemia
Care
Shoulder Dystocia
Published in: Archives of Gynecology and Obstetrics / Issue 3/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05042-x

At a glance: The STEP trials

Springer Medicine

Health care and risk of adverse pregnancy outcomes among diabetic women: an updated meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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