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BMC Pediatrics
Published in: BMC Pediatrics 1/2017

Open Access 01-12-2017 | Study protocol

Neonatal Hyperbilirubinemia in a Marginalized Population on the Thai-Myanmar Border: a study protocol

Authors: Laurence Thielemans, Margreet Trip-Hoving, Germana Bancone, Claudia Turner, Julie A. Simpson, Borimas Hanboonkunupakarn, Michaël Boele van Hensbroek, Patrick van Rheenen, Moo Kho Paw, François Nosten, Rose McGready, Verena I. Carrara

Published in: BMC Pediatrics | Issue 1/2017

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Abstract

Background

This study aims to identify risk factors and the neurodevelopmental impact of neonatal hyperbilirubinemia in a limited-resource setting among a refugee and migrant population residing along the Thai-Myanmar border, an area with a high prevalence of glucose-6-phosphate dehydrogenase-deficiency.

Methods

This is an analytic, observational, prospective birth cohort study including all infants of estimated gestational age equal to or greater than 28 weeks from mothers who followed antenatal care in the Shoklo Malaria Research Unit clinics. At birth, a series of clinical exams and laboratory investigations on cord blood will be carried out. Serum bilirubin will be measured in all infants during their first week of life. All the infants of the cohort will be clinically followed until the age of one year, including monitoring of their neurodevelopment.

Discussion

The strength of this study is the prospective cohort design. It will allow us to collect information about the pregnancy and detect all infants with neonatal hyperbilirubinemia, to observe their clinical response under treatment and to compare their neurodevelopment with infants who did not develop neonatal hyperbilirubinemia. Our study design has some limitations in particular the generalizability of our findings will be limited to infants born after the gestational age of 28 weeks onwards and neurodevelopment to the end of the first year of life.

Trial registration

ClinicalTrials.gov ID NCT02361788, registration date September 1st, 2014.
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Metadata
Title
Neonatal Hyperbilirubinemia in a Marginalized Population on the Thai-Myanmar Border: a study protocol
Authors
Laurence Thielemans
Margreet Trip-Hoving
Germana Bancone
Claudia Turner
Julie A. Simpson
Borimas Hanboonkunupakarn
Michaël Boele van Hensbroek
Patrick van Rheenen
Moo Kho Paw
François Nosten
Rose McGready
Verena I. Carrara
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2017
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-017-0798-8

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