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01-11-2017 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer’s disease: rationale, design, methods, and first baseline data of the Vogel study

Authors: Thomas Polak, Martin J. Herrmann, Laura D. Müller, Julia B. M. Zeller, Andrea Katzorke, Matthias Fischer, Fabian Spielmann, Erik Weinmann, Leif Hommers, Martin Lauer, Andreas J. Fallgatter, Jürgen Deckert

Published in: Journal of Neural Transmission | Issue 11/2017

Abstract

Functional near-infrared spectroscopy (fNIRS) and vagus somatosensory evoked potentials (VSEP) show deviant patterns in subjects with Alzheimer’s disease (AD) compared to healthy controls. We now aimed at testing the predictive value of these methods in the early diagnosis of AD. The Vogel study is a prospective, observational, long-term follow-up study with three time points of investigation within 6 years. Residents of the city of Würzburg born between 1936 and 1941 were recruited. Every participant underwent physical, psychiatric, and laboratory examinations, and performed an intense neuropsychological testing as well as VSEP and NIRS according to the published procedures. 604 subjects were included. Mean age of the participants was 73.9 ± 1.55 years. The most frequent pathological physical and laboratory examination results were observed for blood pressure (62%), body weight (54%), HbA1c (16%), cholesterol (42%), and homocysteine (69%). Comprehensive analysis of cognitive testing showed mild cognitive impairment (MCI) in 12.3% of the patients. Concurrent major depression was found in 6.6% of the patients. We observed a high rate of MCI and somatic comorbidity in our cohort. The high rate of vascular risk factors and depressive symptoms, all of which are known risk factors of AD, is consistent with the notion that there are multiple options to prevent or postpone the onset of AD in a geriatric population like the one of the Vogel studies.

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Title: Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer’s disease: rationale, design, methods, and first baseline data of the Vogel study
Authors: Thomas Polak
Martin J. Herrmann
Laura D. Müller
Julia B. M. Zeller
Andrea Katzorke
Matthias Fischer
Fabian Spielmann
Erik Weinmann
Leif Hommers
Martin Lauer
Andreas J. Fallgatter
Jürgen Deckert
Publication date: 01-11-2017
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 11/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1781-0

At a glance: The STEP trials

Springer Medicine

Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer’s disease: rationale, design, methods, and first baseline data of the Vogel study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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