Top

Published in:

01-04-2009 | Dementias - Short Communication

Auricular vagus somatosensory evoked potentials in vascular dementia

Authors: Thomas Polak, Falko Markulin, Ann-Christine Ehlis, Florian Metzger, Julia B. Langer, Thomas M. Ringel, Andreas J. Fallgatter

Published in: Journal of Neural Transmission | Issue 4/2009

Abstract

A new method for the assessment of vagus nerve function has recently been introduced into clinical practice. In the present study we could show that, contrary to our results in Alzheimer’s disease (AD), in patients with vascular dementia (VaD) vagus sensory evoked potentials (VSEP) did not show statistically significant differences as compared to healthy controls. Thus, we hypothesize that the new method of VSEP could possibly contribute to a differential diagnosis between early cases of AD and VaD.

Beach TG, Wilson JR, Sue LI, Newell A, Poston M, Cisneros R, Pandya Y, Esh C, Connor DJ, Sabbagh, Walker DG, Roher AE (2007) Circle of Willis atherosclerosis: association with Alzheimer’s disease, neuritic plaques and neurofibrillary tangles. Acta Neuropathol (Berl) 113:13–21CrossRef

Bjelik A, Pakaski M, Bereczki E, Gonda S, Juhasz A, Rimanoczy A, Zana M, Janka Z, Santha M, Kalman J (2007) APP mRNA splicing is upregulated in the brain of biglycan transgenic mice. Neurochem Int 50:1–4PubMedCrossRef

Braaten AJ, Parsons TD, McCue R, Sellers A, Burns WJ (2006) Neurocognitive differential diagnosis of dementing diseases: Alzheimer’s Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. Int J Neurosci 116:1271–1293PubMedCrossRef

Cacabelos R (2004) Genomic characterization of Alzheimer’s disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 5:1049–1105PubMedCrossRef

Chiappa KH (1983) Evoked potentials in clinical medicine. Raven Press, New York

Court JA, Perry EK (2003) Neurotransmitter abnormalities in vascular dementia. Int Psychogeriatr 15(Suppl 1):81–87PubMedCrossRef

Demaerschalk BM, Wingerchuk DM (2007) Treatment of vascular dementia and vascular cognitive impairment. Neurologist 13:37–41PubMedCrossRef

Drechsler F, Neuhauser B (1986) Somatosensory trigeminal evoked potentials in normal subjects and in patients with trigeminal neuralgia before and after thermocoagulation of the Ganglion gasseri. Electromyogr Clin Neurophysiol 26:315–326PubMed

Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P, Reiners K, Riederer P (2003) Far field potentials from the brainstem after transcutaneous vagus nerve stimulation. J Neural Trans 110:1437–1443CrossRef

Fallgatter AJ, Ehlis AC, Ringel TM, Herrmann MJ (2005) Age-effect on far field potentials from the brainstem after transcutaneous vagus nerve stimulation. Int J Psychophysiol 56:37–43PubMedCrossRef

Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191PubMed

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Rimmer E, Scazufca M, Alzheimer’s Disease International (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366:2112–2117

Folstein MF, Folstein SE, McHugh PR (1975) “Mini Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198PubMedCrossRef

Hanyu H, Shimizu S, Tanaka Y, Hirao K, Iwamoto T, Abe K (2007) MR features of the substantia innominata and therapeutic implications in dementias. Neurobiol Aging 28:548–554PubMedCrossRef

Hentschel F, Supprian T, Frolich L (2005) Alzheimer’s disease versus vascular dementia—dichotomy or interaction? Fortschr Neurol Psychiatr 73:317–326PubMedCrossRef

Hentschel F, Damian M, Krumm B, Froelich L (2007) White matter lesions—age-adjusted values for cognitively healthy and demented subjects. Acta Neurol Scand 115:174–180PubMedCrossRef

Jaspers HH (1958) Report of the committee on methods of clinical examination in electroencephylography. Electroencephalogr Clin Neurophysiol 10:370–371CrossRef

Jellinger KA (2004) Pathology and pathophysiology of vascular cognitive impairment. A critical update. Panminerva Med 46:217–226

Jellinger KA (2005) Understanding the pathology of vascular cognitive impairment. J Neurol Sci 229–230:57–63PubMedCrossRef

Jellinger KA (2007) The enigma of vascular cognitive disorder and vascular dementia. Acta Neuropathol (Berl) 113:349–388CrossRef

Loeb C, Meyer JS (2000) Criteria for diagnosis of vascular dementia. Arch Neurol 57:1382–1383PubMedCrossRef

Onishi J, Suzuki Y, Yoshiko K, Hibino S, Iguchi A (2005) Predictive model for assessing cognitive impairment by quantitative electroencephalography. Cogn Behav Neurol 18:179–184PubMedCrossRef

Parvizi J, Van Hoesen GW, Damasio A (2001) The selective vulnerability of brain stem nuclei to Alzheimer’s disease. Ann Neurol 49:53–66PubMedCrossRef

Perry E, Ziabreva I, Perry R, Aarsland D, Ballard C (2005) Absence of cholinergic deficits in “pure” vascular dementia. Neurology 64:132–133PubMed

Peukert ET, Filler TJ (2002) The nerve supply of the human auricle. Clin Anatom 15:35–37CrossRef

Picton TW, Hillyard SA, Krausz HI, Galambos R (1974) Human auditory evoked potentials: I. Evaluation of components. Electroencephalogr Clin Neurophysiol 36:179–190PubMedCrossRef

Pirchl M, Marksteiner J, Humpel C (2006) Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer’s disease. Neurol Res 28:657–664PubMedCrossRef

Polak T, Ehlis AC, Langer J, Plichta M, Metzger F, Ringel TM, Fallgatter AJ (2007) Non-invasive measurement of vagus activity in the brainstem—a methodological progress towards earlier diagnosis of dementias? J Neural Transm 110:1437–1443

Reed BR, Mungas DM, Kramer JH, Ellis W, Vinters HV, Zarow C, Jagust WJ, Chui HC (2007) Profiles of neuropsychological impairment in autopsy-defined Alzheimer’s disease and cerebrovascular disease. Brain 130:731–739PubMedCrossRef

Roman GC (2004) Vascular dementia. Advances in nosology, diagnosis, treatment and prevention. Panminerva Med 46:207–215PubMed

Roman GC (2005) Cholinergic dysfunction in vascular dementia. Curr Psychiatry Rep 7:18–26PubMedCrossRef

Roman GC, Kalaria RN (2006) Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiol Aging 27:1769–1785PubMedCrossRef

Roy S, Rauk A (2005) Alzheimer’s disease and the ‘ABSENT’ hypothesis: mechanism for amyloid beta endothelial and neuronal toxicity. Med Hypotheses 65:123–137PubMedCrossRef

Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T (2004) Links between the pathology of Alzheimer’s disease and vascular dementia. Neurochem Res 29:1257–1266PubMedCrossRef

Shields RW Jr (1993) Functional anatomy of the autonomic nervous system. J Clin Neurophysiol 10(1):2–13

Stechison MT (1993) The trigeminal evoked potential: Part II. Intraoperative recording of short latency responses. Neurosurgery 33:639–644PubMedCrossRef

Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800PubMed

Tomimoto H, Ohtani R, Shibata M, Nakamura N, Ihara M (2005) Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dement Geriatr Cogn Disord 19:282–288PubMedCrossRef

Van der Flier WM, Barkhof F, Scheltens P (2007) Shifting paradigms in dementia: toward stratification of diagnosis and treatment using MRI. Ann N Y Acad Sci 1097:215–224PubMedCrossRef

Van Harten B, Laman DM, van Duijn H, Knol DL, Stam CJ, Scheltens P, Weinstein HC (2006) The auditory oddball paradigm in patients with vascular cognitive impairment: a prolonged latency of the N2 complex. Dement Geriatr Cogn Disord 21:322–327PubMedCrossRef

Von Bernhardi R, Alarcon R, Mezzano D, Fuentes P, Inestrosa NC (2005) Blood cells cholinesterase activity in early stage Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 19:204–212CrossRef

Weller RO, Cohen NR, Nicoll JA (2004) Cerebrovascular disease and the pathophysiology of Alzheimer’s disease. Implications for therapy. Panminerva Med 46:239–251

Title: Auricular vagus somatosensory evoked potentials in vascular dementia
Authors: Thomas Polak
Falko Markulin
Ann-Christine Ehlis
Florian Metzger
Julia B. Langer
Thomas M. Ringel
Andreas J. Fallgatter
Publication date: 01-04-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 4/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0202-4

At a glance: The STEP trials

Springer Medicine

Auricular vagus somatosensory evoked potentials in vascular dementia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2009

Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

Expression of GluR6 kainate receptor subunit in granular layer of weaver mouse cerebellum

Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson’s disease patients

Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release

Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood

Hyperserotonemia in autism: activity of 5HT-associated platelet proteins