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Head & Face Medicine

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Open Access 01-12-2015 | Research

NCAM (CD56) Expression in keratin-producing odontogenic cysts: aberrant expression in KCOT

Authors: Beatriz Vera-Sirera, Leopoldo Forner-Navarro, Francisco Vera-Sempere

Published in: Head & Face Medicine | Issue 1/2015

Abstract

Objective

To investigate immunohistochemically the expression of neural cell adhesion molecule (NCAM), which has been identified as a signaling receptor with frequent reactivity in ameloblastomas (AB), in a series of keratin-producing odontogenic cysts (KPOCs).

Material and methods

Immunohistochemical expression of NCAM, using a monoclonal antibody, was determined in a series of 58 KPOCs comprising 12 orthokeratinized odontogenic cysts (OOCs) and 46 keratocystic odontogenic tumors (KCOTs), corresponding to 40 non-syndromic KCOT (NS-KCOTs) and 6 syndromic KCOT (S-KCOTs), associated with nevic basocellular syndrome (NBCS).

Results

NCAM expression was negative in all OOCs, but 36.45% of KCOTs exhibited focal and heterogeneous expression at the basal cell level, as well as in basal budding areas and the basal cells of daughter cysts. The latter two locations were especially applicable to S-KCOTs, with focal NCAM reactivity occurring in 66.66% of cases.

Conclusions

Aberrant NCAM expression, in KCOTs but especially in S-KCOTs, together with its immunomorphological location, suggests that this adhesion molecule and signaling receptor plays a role in the pathogenesis of KCOTs, with a probable impact on lesional recurrence.

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Title: NCAM (CD56) Expression in keratin-producing odontogenic cysts: aberrant expression in KCOT
Authors: Beatriz Vera-Sirera
Leopoldo Forner-Navarro
Francisco Vera-Sempere
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Head & Face Medicine / Issue 1/2015
Electronic ISSN: 1746-160X
DOI: https://doi.org/10.1186/s13005-015-0060-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

NCAM (CD56) Expression in keratin-producing odontogenic cysts: aberrant expression in KCOT

Abstract

Objective

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusions

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