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Published in: Oral and Maxillofacial Surgery 2/2012

01-06-2012 | Review Article

Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour

Authors: Darpan Bhargava, Ashwini Deshpande, M. Anthony Pogrel

Published in: Oral and Maxillofacial Surgery | Issue 2/2012

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Abstract

Purpose

The World Health Organization (WHO) has reclassified ‘odontogenic keratocyst’ (OKC) to ‘keratocystic odontogenic tumour’ (KCOT) in 2005. Currently, this tumour is classified as a benign neoplasm of odontogenic origin and not as a cyst. This article reviews and discusses history, classification scheme, aetiology and pathogenesis, molecular and genetic basis, incidence, epidemiology and site, clinical features, imaging, histopathology, immunohistochemistry, treatment options, prognosis, recurrence and malignant transformation of KCOT, with emphasis on understanding the basis of reclassification as ‘keratocystic odontogenic tumour’.

Methods

A systematic search and review of the literature was carried out in the online database of the United States National Library of Medicine to identify eligible titles for the study.

Results

Current evidence suggests that the scientific community still continues to use the term ‘odontogenic keratocyst’ more favourably than ‘keratocystic odontogenic tumour’.

Conclusion

The online database search indicates that the scientific community still continues to use the term ‘odontogenic keratocyst’ more favourably than ‘keratocystic odontogenic tumour’. At this juncture, where the terminology has changed from a cyst to a tumour, a thorough review of literature on KCOT is presented.
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Metadata
Title
Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour
Authors
Darpan Bhargava
Ashwini Deshpande
M. Anthony Pogrel
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Oral and Maxillofacial Surgery / Issue 2/2012
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-011-0302-9

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