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28-11-2022 | Nausea | Maternal-Fetal Medicine

Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Authors: Nana Li, Zhiwei Xue, Hongmei Xu, Ping Yang, Ke Wang, Lu Li, Hong Kang, Meixian Wang, Ying Deng, Xiaohong Li, Yanping Wang, Jun Zhu, Ping Yu, Shu Zhou

Published in: Archives of Gynecology and Obstetrics | Issue 6/2023

Abstract

Purpose

To evaluate the impact of Nausea and Vomiting in Pregnancy (NVP) on the risk of Preterm Birth (PTB) and Low Birth Weight (LBW), and explore the effect of genetic polymorphisms on the severity of NVP.

Methods

A prospective study was conducted. Participants’ experience of NVP prior to 12 gestational weeks were evaluated by a Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale. 11 Single Nucleotide Polymorphisms (SNPs) loci located in growth differentiation factor 15 (GDF15) and leucine-rich repeat containing 25 (LRRC25) gene of chr19p13.11 and intergenic region of chr4q12 were genotyped, which were implicated as genetic risk factors for NVP. Logistic regression models were applied to determine the effect of NVP in the first trimester on the risk of PTB and LBW, and genetic polymorphisms on the risk of NVP.

Results

Among 413 pregnant women, the incidence of nausea and vomiting was 85.5% (n = 353) in the first trimester, including 38.7% (n = 160) mild vomiting, 42.6% (n = 176) moderate vomiting and 4.1% (n = 17) severe vomiting. 33 were PTB, 20 were LBW. Compared with pregnant women without NVP, women with mild, moderate or severe NVP in the first trimester were not associated with the risk of PTB and LBW. Besides, the polymorphisms of 11 SNPs loci were not associated with the risk of NVP.

Conclusions

Our study indicated that symptoms of nausea and vomiting in the first trimester were not significantly associated with PTB and LBW, and there were also no associations between GDF15 and LRRC25 polymorphisms and NVP.

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Title: Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study
Authors: Nana Li
Zhiwei Xue
Hongmei Xu
Ping Yang
Ke Wang
Lu Li
Hong Kang
Meixian Wang
Ying Deng
Xiaohong Li
Yanping Wang
Jun Zhu
Ping Yu
Shu Zhou
Publication date: 28-11-2022
Publisher: Springer Berlin Heidelberg
Keywords: Nausea
Hyperemesis Gravidarum
Vomiting
Premature Birth
Published in: Archives of Gynecology and Obstetrics / Issue 6/2023
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-022-06851-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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