Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Clinical Rheumatology
Published in: Clinical Rheumatology 8/2019

01-08-2019 | Myocarditis | Case Based Review

A misdiagnosed case of antisynthetase syndrome complicated by myocarditis: when the cardiologist deals with rheumatology

Authors: Paolo Diego L’Angiocola, Luisa Mattei, Gerardina Lardieri

Published in: Clinical Rheumatology | Issue 8/2019

Login to get access

Abstract

We report a case of a 56-year-old woman with an alleged diagnosis of an acute coronary syndrome that was later correctly identified in our Cardiology Unit as antisynthetase syndrome (AS) with inflammatory cardiac involvement. In this case report, we focus on clinical features of this rare autoimmune disease aiming to provide useful tips to achieve correct differential diagnosis according to updated international guidelines and recommendations, especially in cases of concurrent disease-related myocarditis.
Literature
1.
Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M (1983) The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of poly-myositis with interstitial pulmonary fibrosis. Arthritis Rheum 26:604–611CrossRefPubMed
2.
Brouwer R, Hengstman GJ, Vree Egberts W, Ehrfeld H, Bozic B, Ghirardello A et al (2001) Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 60:116–123CrossRefPubMedPubMedCentral
3.
Sharma K, Orbai A-M, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S (2014) Brief report: antisynthetase syndrome-associated myocarditis. J Card Fail 20:939–945CrossRefPubMedPubMedCentral
4.
5.
6.
Elamm C, Fairweather D, Cooper LT (2012) Pathogenesis and diagnosis of myocarditis. Heart 98:835–840CrossRefPubMed
7.
Sinagra G, Anzini M, Pereira NL, Bussani R, Finocchiaro G, Bar-tunek J et al (2016) Myocarditis in clinical practice. Mayo Clin Proc 91:1256–1266CrossRefPubMed
8.
Ammirati E, Cipriani M, Lilliu M, Sormani P, Varrenti M, Raineri C, Petrella D, Garascia A, Pedrotti P, Roghi A, Bonacina E, Moreo A, Bottiroli M, Gagliardone MP, Mondino M, Ghio S, Totaro R, Turazza FM, Russo CF, Oliva F, Camici PG, Frigerio M (2017) Survival and left ventricular function changes in fulminant versus nonfulminant acute myocarditis. Circulation 136:529–545CrossRefPubMed
9.
Dieval C, Deligny C, Meyer A, Cluzel P, Champtiaux N, Lefevre G, Saadoun D, Sibilia J, Pellegrin JL, Hachulla E, Benveniste O, Hervier B (2015) Myocarditis in patients with antisynthetase syndrome: prevalence, presentation, and outcomes. Medicine (Baltimore) 94:e798CrossRef
10.
11.
12.
13.
Allanore Y, Vignaux O, Arnaud L, Puéchal X, Pavy S, Duboc D, Legmann P, Kahan A (2006) Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging. Ann Rheum Dis 65(2):249–252CrossRefPubMedPubMedCentral
14.
Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E (2013) Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. J Cardiovasc Magn Reson 15(91):2013
15.
Lurz P, Luecke C, Eitel I, Föhrenbach F, Frank C, Grothoff M, de Waha S, Rommel KP, Lurz JA, Klingel K, Kandolf R, Schuler G, Thiele H, Gutberlet M (2016) Comprehensive cardiac magnetic resonance imaging in patients with suspected myocarditis: the MyoRacer-trial. J Am Coll Cardiol 67:1800–1811CrossRefPubMed
16.
17.
Caforio AL, Pankuweit S, Arbustini E et al (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34(33):2636–2648, 2648a-2648d. https://​doi.​org/​10.​1093/​eurheartj/​eht210 CrossRefPubMed
18.
19.
Brambatti M, Matassini MV, Adler ED, Klingel K, Camici PG, Ammirati E (2017) Eosinophilic myocarditis: characteristics, treatment, and outcomes. J Am Coll Cardiol 70:2363–2375CrossRefPubMed
20.
Cooper LT Jr, Hare JM, Tazelaar HD, Edwards WD, Starling RC, Deng MC, Menon S, Mullen GM, Jaski B, Bailey KR, Cunningham MW, Dec GW (2008) Usefulness of immunosuppression for giant cell myocarditis. Am J Cardiol 102:1535–1539CrossRefPubMedPubMedCentral
21.
Ammirati E, Oliva F, Belli O, Bonacina E, Pedrotti P, Turazza FM, Roghi A, Paino R, Martinelli L, Frigerio M (2016) Giant cell myocarditis successfully treated with antithymocyte globuline and extracorporeal membrane oxygenation for 21 days. J Cardiovasc Med (Hagerstown) 17(Suppl 2):e151–e153CrossRef
22.
Metadata
Title
A misdiagnosed case of antisynthetase syndrome complicated by myocarditis: when the cardiologist deals with rheumatology
Authors
Paolo Diego L’Angiocola
Luisa Mattei
Gerardina Lardieri
Publication date
01-08-2019
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 8/2019
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-019-04527-z

Other articles of this Issue 8/2019

Clinical Rheumatology 8/2019 Go to the issue

Original Article

Extractable synovial fluid in inflammatory and non-inflammatory arthritis of the knee

Brief Report

Uncommon presentations in ANCA vasculitis: clinical characteristics and outcomes

Original Article

Hypertension is associated with increased age at the onset of psoriasis and a higher body mass index in psoriatic disease

Original Article

Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology

Letter to the Editor

Letter to the editor: mobile applications for patients with gout in China

Correction

Correction to: Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits