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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-12-2015 | Research

Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure

Authors: Pen-An Liao, Gigin Lin, Shang-Yueh Tsai, Chao-Hung Wang, Yu-Hsiang Juan, Yu-Ching Lin, Ming-Ting Wu, Lan-Yan Yang, Min-Hui Liu, Tsun-Ching Chang, Yu-Chun Lin, Yu-Chieh Huang, Pei-Ching Huang, Jiun-Jie Wang, Shu-Hang Ng, Koon-Kwan Ng

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2017

Abstract

Background

Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic resonance spectroscopy (¹H-MRS) and left ventricular (LV) function assessed on cardiovascular magnetic resonance (CMR) in patients who were hospitalized with HF.

Methods

A total of 50 patients who were discharged after hospitalization for acute HF and 21 age- and sex-matched controls were included in the study. Myocardial TG content and LV parameters (function and mass) were measured on a 3.0 T MR scanner. Fatty acid (FA) and unsaturated fatty acid (UFA) content was normalized against water (W) using the LC-Model algorithm. The patient population was dichotomized according to the left ventricular ejection fraction (LVEF, <50 % or ≥ 50 %).

Results

H-MRS data were available for 48 patients and 21 controls. Of the 48 patients, 25 had a LVEF <50 % (mean, 31.2 %), whereas the remaining 23 had a normal LVEF (mean, 60.2 %). Myocardial UFA/W ratio was found to differ significantly in patients with low LVEF, normal LVEF, and controls (0.79 % vs. 0.21 % vs. 0.14 %, respectively, p = 0.02). The myocardial UFA/TG ratio was associated with LV mass (r = 0.39, p < 0.001) and modestly related to LV end-diastolic volume (LVEDV; r = 0.24, p = 0.039). We also identified negative correlations of the myocardial FA/TG ratio with both LV mass (r = -0.39, p < 0.001) and LVEDV (r = -0.24, p = 0.039).

Conclusions

As compared with controls, patients who were discharged after hospitalization for acute HF had increased myocardial UFA content; furthermore, UFA was inversely related with LVEF, LV mass and, to a lesser extent, LVEDV. Our study may stimulate further research on the measure of myocardial UFA content by ¹H-MRS for outcome prediction.

Trial registration

ClinicalTrial.gov: NCT02378402. Registered 27/02/2015

Available only for authorised users

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Title: Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure
Authors: Pen-An Liao
Gigin Lin
Shang-Yueh Tsai
Chao-Hung Wang
Yu-Hsiang Juan
Yu-Ching Lin
Ming-Ting Wu
Lan-Yan Yang
Min-Hui Liu
Tsun-Ching Chang
Yu-Chun Lin
Yu-Chieh Huang
Pei-Ching Huang
Jiun-Jie Wang
Shu-Hang Ng
Koon-Kwan Ng
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2017
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/s12968-016-0228-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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