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01-05-2016 | Review

Myocardial injury associated with transcatheter aortic valve implantation (TAVI)

Authors: Won-Keun Kim, Christoph Liebetrau, Arnaud van Linden, Johannes Blumenstein, Luise Gaede, Christian W. Hamm, Thomas Walther, Helge Möllmann

Published in: Clinical Research in Cardiology | Issue 5/2016

Abstract

Transcatheter aortic valve implantation (TAVI) has emerged as an important treatment option for elderly patients with symptomatic aortic stenosis whose risk is too high or prohibitive for conventional surgery. Despite notable progress during the past decade, continuous efforts directed at further improvement of procedural safety and performance are required, especially considering expanding indications for interventional treatment options among lower-risk populations. One issue that needs to be addressed is myocardial damage, which can frequently be observed after TAVI and has been linked to worse prognosis. Yet, knowledge concerning the underlying mechanisms and clinical impact remains scarce, and further investigation in this field is warranted. In this review, we provide a contemporary summary of the types of myocardial injury associated with TAVI, including access-related injury, mechanical trauma and ischemia, the role of myocardial biomarkers, and the impact on left ventricular function, with emphasis on potential mechanisms and clinical implications.

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Title: Myocardial injury associated with transcatheter aortic valve implantation (TAVI)
Authors: Won-Keun Kim
Christoph Liebetrau
Arnaud van Linden
Johannes Blumenstein
Luise Gaede
Christian W. Hamm
Thomas Walther
Helge Möllmann
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Clinical Research in Cardiology / Issue 5/2016
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-015-0949-6

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