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Journal of Cardiovascular Translational Research
Published in: Journal of Cardiovascular Translational Research 1/2022

01-02-2022 | Myocardial Infarction | Review

Key Roles of RGD-Recognizing Integrins During Cardiac Development, on Cardiac Cells, and After Myocardial Infarction

Authors: Olivier Schussler, Juan C. Chachques, Marco Alifano, Yves Lecarpentier

Published in: Journal of Cardiovascular Translational Research | Issue 1/2022

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Abstract

Cardiac cells interact with the extracellular matrix (ECM) proteins through integrin mechanoreceptors that control many cellular events such as cell survival, apoptosis, differentiation, migration, and proliferation. Integrins play a crucial role in cardiac development as well as in cardiac fibrosis and hypertrophy. Integrins recognize oligopeptides present on ECM proteins and are involved in three main types of interaction, namely with collagen, laminin, and the oligopeptide RGD (Arg-Gly-Asp) present on vitronectin and fibronectin proteins. To date, the specific role of integrins recognizing the RGD has not been addressed. In this review, we examine their role during cardiac development, their role on cardiac cells, and their upregulation during pathological processes such as heart fibrosis and hypertrophy. We also examine their role in regenerative and angiogenic processes after myocardial infarction (MI) in the peri-infarct area. Specific targeting of these integrins may be a way of controlling some of these pathological events and thereby improving medical outcomes.
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Metadata
Title
Key Roles of RGD-Recognizing Integrins During Cardiac Development, on Cardiac Cells, and After Myocardial Infarction
Authors
Olivier Schussler
Juan C. Chachques
Marco Alifano
Yves Lecarpentier
Publication date
01-02-2022
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 1/2022
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-021-10154-4

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