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01-12-2021 | Myocardial Infarction | Sleep Breathing Physiology and Disorders • Original Article

Snoring increases the development of coronary artery disease: a systematic review with meta-analysis of observational studies

Authors: Junxiang Liu, Yangzhen Shao, Jing Bai, Yafei Shen, Yifei Chen, Dongliang Liu, Haoran Wang

Published in: Sleep and Breathing | Issue 4/2021

Abstract

Purpose

Snoring is one of the cardinal presentations of obstructive sleep apnea (OSA) and is more common than OSA. Abundant evidence has suggested a robust association between OSA and coronary artery disease (CAD). However, whether or not snoring alone is related to a higher risk of CAD is unknown. This study systematically reviewed observational studies with meta-analysis to evaluate the linkage between snoring and CAD.

Methods and results

We searched PubMed and Embase and retrieved 13 articles focusing on the relationship between snoring and CAD. These articles included a total of 151,366 participants and 9099 CAD patients. Quantitative analysis indicated that snoring was associated with a 28% (RR: 1.28, 95% CI: 1.13 to 1.45, P < 0.001) increase in the risk of developing CAD.

Conclusions

Snorers are exposed to a 28% increased risk for CAD. Although the association may be partly mediated through OSA, most snorers are not affected by apnea. Given the high prevalence of snoring and the disease burden of CAD in the general population, screening for snoring may be worthwhile for the early prevention of CAD.

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Title: Snoring increases the development of coronary artery disease: a systematic review with meta-analysis of observational studies
Authors: Junxiang Liu
Yangzhen Shao
Jing Bai
Yafei Shen
Yifei Chen
Dongliang Liu
Haoran Wang
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keywords: Myocardial Infarction
Arterial Diseases
Snoring
Published in: Sleep and Breathing / Issue 4/2021
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02345-9

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