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The International Journal of Cardiovascular Imaging

Published in:

01-09-2018 | Original Paper

Myocardial flow reserve derived by dynamic perfusion single-photon emission computed tomography reflects the severity of coronary atherosclerosis

Authors: Nobuo Iguchi, Yuko Utanohara, Yasuhiro Suzuki, Makoto Suzuki, Kenichi Hagiya, Ryosuke Higuchi, Itaru Takamisawa, Tetsuya Tobaru, Tetsuya Sumiyoshi, Mitsuaki Isobe

Published in: The International Journal of Cardiovascular Imaging | Issue 9/2018

Abstract

A novel single-photon emission computed tomography (SPECT) camera was developed to evaluate dynamic myocardial perfusion flow. However, it is unclear whether myocardial flow reserve (MFR) derived by dynamic perfusion SPECT using the novel SPECT camera (D-SPECT) reflects the severity of coronary atherosclerosis. In the present study, we therefore examined the relationship between MFR using D-SPECT and severity of coronary lesions. The study population comprised 40 patients who underwent both a myocardial dynamic perfusion SPECT study and invasive coronary angiography. The severity of coronary atherosclerosis was evaluated using the Gensini score. All patients underwent a rest/stress SPECT imaging protocol using Tc-99m-sestamibi, and dynamic acquisition was performed. Stress and rest flow was evaluated, and the global and regional MFR was calculated. Global MFR showed a significant negative correlation with Gensini score (r = − 0.345, p = 0.037). Multiple linear regression analysis showed that only global MFR was independently related to Gensini score (p = 0.018). Regional MFR was significantly lower in regions with 90% ≤ stenotic lesions compared with regions with < 90% stenotic lesions (p = 0.009). Global MFR derived by dynamic perfusion SPECT using D-SPECT reflects the severity of coronary atherosclerosis. Further, regional MFR is modulated by severe coronary artery stenotic lesions.

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Title: Myocardial flow reserve derived by dynamic perfusion single-photon emission computed tomography reflects the severity of coronary atherosclerosis
Authors: Nobuo Iguchi
Yuko Utanohara
Yasuhiro Suzuki
Makoto Suzuki
Kenichi Hagiya
Ryosuke Higuchi
Itaru Takamisawa
Tetsuya Tobaru
Tetsuya Sumiyoshi
Mitsuaki Isobe
Publication date: 01-09-2018
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 9/2018
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-018-1358-5

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