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Current Heart Failure Reports

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01-06-2018 | Clinical Trials (J. Butler, Section Editor)

Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials

Authors: Kunal N. Bhatt, Javed Butler

Published in: Current Heart Failure Reports | Issue 3/2018

Abstract

Purpose of review

Several novel therapeutics being tested in patients with heart failure are based on myocardial energetics. This review will provide a summary of the recent trials in this area, including therapeutic options targeting various aspects of cellular and mitochondrial metabolism.

Recent findings

Agents that improve the energetic balance in myocardial cells have the potential to improve clinical heart failure status. The most promising therapies currently under investigation in this arena include (1) elamipretide, a cardiolipin stabilizer; (2) repletion of iron deficiency with intravenous ferrous carboxymaltose; (3) coenzyme Q10; and (4) the partial adenosine receptor antagonists capadenoson and neladenosone.

Summary

Myocardial energetics-based therapeutics are groundbreaking in that they utilize novel mechanisms of action to improve heart failure symptoms, without causing the adverse neurohormonal side effects associated with current guideline-based therapies. The drugs appear likely to be added to the heart failure therapy armamentarium as adjuncts to current regimens in the near future.

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Title: Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials
Authors: Kunal N. Bhatt
Javed Butler
Publication date: 01-06-2018
Publisher: Springer US
Published in: Current Heart Failure Reports / Issue 3/2018
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI: https://doi.org/10.1007/s11897-018-0386-8

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