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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 4/2020

01-04-2020 | Myelodysplastic Syndrome | Original Article

Dual-layer detector spectral CT versus magnetic resonance imaging for the assessment of iron overload in myelodysplastic syndromes and aplastic anemia

Authors: Quanmei Ma, Juan Hu, Wei Yang, Yang Hou

Published in: Japanese Journal of Radiology | Issue 4/2020

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Abstract

Background

The purpose of this study is to investigate the performance of dual-layer detector spectral CT for iron deposition compared to magnetic resonance imaging (MRI) T2* imaging.

Methods

Thirty-one patients with a clinical history of myelodysplastic syndromes and aplastic anemia underwent liver and cardiac T2*-weighted unenhanced MRI on a three-tesla MRI scanner, and underwent unenhanced CT scan laterally on a 128-row spectral detector CT. R2* values of the liver, septal muscle, and paraspinal muscle were calculated. Attenuation differences (ΔH) in the liver and myocardium were calculated between the lower (50 keV) and higher (120 keV) energy levels.

Results

The liver and cardiac T2* values were 9.54 ± 5.63 ms and 21.41 ± 2.44 ms, respectively. The liver-to-muscle and myocardium-to-muscle T2* value ratios were 0.37 ± 0.23 and 0.79 ± 0.19, respectively. The liver and cardiac ΔH were − 1.13 ± 4.24 HU and 2.22 ± 4.41 HU, respectively. There was a strong linear correlation between the liver R2* and ΔH (r = − 0.832, P < 0.001), but weak correlation existed between the cardiac R2* and ΔH (P = 0.041).

Conclusions

Dual-layer detector spectral unenhanced CT seemed to be equally valuable to MRI T2* imaging for evaluating liver iron overload.
Literature
1.
Porter J, de Witte T, Cappellini M, Gattermann N. New insights into transfusion-related iron toxicity: implications for the oncologist. Crit Rev Oncol Hematol. 2016;99(10):261–71.CrossRef
2.
Gautam R, Wallace DF, Nathan SV. Hepcidin: regulation of the master iron regulator. Biosci Rep. 2015;35(3):e00192.CrossRef
3.
Jabbour E, Ghanem H, Huang X, Ravandi F, Garciamanero G, O'Brien S, et al. Acute myeloid leukemia after myelodysplastic syndrome and failure of therapy with hypomethylating agents: an emerging entity with a poor prognosis. Clin Lymphoma Myeloma Leuk. 2014;14(2):93–7.CrossRef
4.
Labranche R, Gilbert G, Cerny M, Vu K-N, Soulières D, Olivié D, et al. Liver iron quantification with MR imaging: a primer for radiologists. RadioGraphics. 2018;38(2):392–412.CrossRef
5.
Coates TD. Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radic Biol Med. 2014;72(6):23–40.CrossRef
6.
Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, et al. Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association. Circulation. 2013;128(13):E203.
7.
Krittayaphong R, Zhang S, Saiviroonporn P, Viprakasit V, Tanapibunpon P, Komoltri C, et al. Detection of cardiac iron overload with native magnetic resonance T1 and T2 mapping in patients with thalassemia. Int J Cardiol. 2017;248(5):421–6.CrossRef
8.
He T. Cardiovascular magnetic resonance T2* for tissue iron assessment in the heart. Quant Imaging Med Surg. 2014;4(5):407–12.PubMedPubMedCentral
9.
Chirico V, Rigoli L, Lacquaniti A, Salpietro V, Piraino B, Amorini M, et al. Endocrinopathies, metabolic disorders, and iron overload in major and intermedia thalassemia: serum ferritin as diagnostic and predictive marker associated with liver and cardiac T2* MRI assessment. Eur J Haematol. 2015;94(5):404–12.CrossRef
10.
Ibrahim E-SH, Bowman AW. Characterization of myocardial iron overload by dual-energy computed tomography compared to T2* MR. A phantom study. In: Conf Proc IEEE Eng Med Biol Soc pp. 5133–6. 2014.
11.
Luo XF, Yang Y, Yan J, Xie XQ, Zhang H, Chai WM, et al. Virtual iron concentration imaging based on dual-energy CT for noninvasive quantification and grading of liver iron content: an iron overload rabbit model study. Eur Radiol. 2015;25(9):2657–64.CrossRef
12.
Tsai YS, Chen JS, Wang CK, Lu CH, Cheng CN, Kuo CS, et al. Quantitative assessment of iron in heart and liver phantoms using dual-energy computed tomography. Exp Ther Med. 2014;8(3):907–12.CrossRef
13.
Ibrahim E-SH, Bowman AW, Khalifa AM. Dual-energy computed tomography versus magnetic resonance imaging for the assessment of iron overload. In: 2nd Middle East Conference on Biomedical Engineering. 2014: 5–8.
14.
Fischer MA, Reiner CS, Raptis D, Donati O, Goetti R, Clavien PA, et al. Quantification of liver iron content with CT-added value of dual-energy. Eur Radiol. 2011;21(8):1727–32.CrossRef
15.
Majd Z, Haghpanah S, Ajami GH, Matin S, Namazi H, Bardestani M, et al. Serum ferritin levels correlation with Heart and liver MRI and LIC in patients with transfusion-dependent thalassemia. Iran Red Crescent Med J. 2015;17(4):e24959.CrossRef
16.
Azarkeivan A, Hashemieh M, Akhlaghpoor S, Shirkavand A, Yaseri M, Sheibani K. Relation between serum ferritin and liver and heart MRI T2* in beta thalassaemia major patients. East Mediterr Health J. 2013;19(8):727–32.CrossRef
17.
Felipe A, Guadalupe E, Druso P, Carlos M, Pablo S, Oscar C, et al. Serum ferritin is associated with metabolic syndrome and red meat consumption. Oxidative Med Cell Longev. 2015;5:769–39.
18.
Sharma S, Fischer R, Schoennagel B, Nielsen P, Kooijman H, Yamamura J, et al. MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med. 2017;78(1):264–70.CrossRef
19.
Chan WC, Tejani Z, Budhani F, Massey C, Haider MA. R2* as a surrogate measure of FerriScan iron quantification in thalassemia. J Magn Reson Imaging. 2014;39(4):1007–111.CrossRef
20.
Nienhuis AW, Nathan DG. Pathophysiology and clinical manifestations of the β-thalassemias. Cold Spring Harbor Perspect Med. 2012;2(12):a011726.CrossRef
21.
Hernando D, Levin YS, Sirlin CB, Reeder SB. Quantification of liver iron with MRI: state of the art and remaining challenges. J Magn Reson Imaging. 2014;40(5):1003–211.CrossRef
22.
Storey P, Thompson AA, Carqueville CL, de Freitas RA, Rigsby CK. R2* imaging of transfusional iron burden at 3 T and comparison with 1.5 T. J Magn Reson Imaging. 2007;25(3):540–7.CrossRef
23.
Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005;106(4):1460–5.CrossRef
24.
Hernando D, Kramer JH, Reeder SB. Multipeak fat-corrected complex R2* relaxometry: theory, optimization, and clinical validation. Magn Reson Med. 2013;70(5):1319–31.CrossRef
25.
Abadia AF, Grant KL, Carey KE, Bolch WE, Morin RL. Spatial distribution of iron within the normal human liver using dual-source dual-energy CT imaging. Investig Radiol. 2017;52(11):693–700.CrossRef
26.
Luo XF, Xie XQ, Cheng S, Yang Y, Yan J, Zhang H, et al. Dual-energy CT for patients suspected of having liver iron overload: can virtual iron content imaging accurately quantify liver iron content? Radiology. 2015;277(1):95–103.CrossRef
27.
Joe E, Kim SH, Lee KB, Jang JJ, Lee JY, Lee JM. Feasibility and accuracy of dual-source dual-energy CT for noninvasive determination of hepatic iron accumulation. Int J Med Radiol. 2012;262(1):126–35.
28.
Ma J, Song ZQ, Yan FH. Separation of hepatic iron and fat by dual-source dual-energy computed tomography based on material decomposition: an animal study. PLoS ONE. 2014;9(10):e110964.CrossRef
Metadata
Title
Dual-layer detector spectral CT versus magnetic resonance imaging for the assessment of iron overload in myelodysplastic syndromes and aplastic anemia
Authors
Quanmei Ma
Juan Hu
Wei Yang
Yang Hou
Publication date
01-04-2020
Publisher
Springer Singapore
Published in
Japanese Journal of Radiology / Issue 4/2020
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-020-00921-9

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